Interaction of rat lin-10 with brain-enriched F-actin-binding protein, neurabin-II/spinophilin
Interaction of rat lin-10 with brain-enriched F-actin-binding protein, neurabin-II/spinophilin
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DOI：
10.1006/bbrc.1998.8243
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发表时间：
1998-03-06
影响因子：
3.1
通讯作者：
Takai, Y
中科院分区：
文献类型：
--
作者：
Ide, N;Hata, Y;Takai, Y
我们最近分离出了秀丽隐杆线虫LIN-10产物的一个大鼠同源物。虽然大鼠LIN-10在各种组织的胞浆和膜组分都有表达，但在脑内仅分布于膜组分，在突触质膜和突触后密度组分中有丰富的表达。我们在这里从大鼠脑中分离到一个与LIN-10相互作用的蛋白，并将其鉴定为Neurabin-II/Spinophlin，它是最近被分离出来的一种与蛋白磷酸酶I和F-肌动蛋白相互作用的蛋白。Neurabin-II/SPIN广泛表达于脑内，尤其在突触质膜和突触后密度组分表达丰富。我们讨论了大鼠LIN-10与Neurabin-II/SPIN相互作用的生理意义。(C)1998年学术出版社。
We have recently isolated a rat homologue of the Caenorrhabditis elegans lin-10 product. Although rat lin-10 is expressed in the cytosol and membrane fractions of various tissues, it is distributed only in the membrane fraction in brain where it is enriched in the synaptic plasma membrane and postsynaptic density fractions. We have isolated here a rat lin-10-interacting protein from rat brain and identified it to be neurabin-II/spinophilin, which has recently been isolated as a protein interacting with protein phosphatase I and F-actin. Neurabin-II/spinophilin is ubiquitously expressed but enriched in brain, especially in the synaptic plasma membrane and postsynaptic density fractions. We discuss the physiological significance of the interaction of rat lin-10 with neurabin-II/spinophilin. (C) 1998 Academic Press.