Value of alpha 1-acid glycoprotein in the diagnosis of feline infectious peritonitis
Value of alpha 1-acid glycoprotein in the diagnosis of feline infectious peritonitis
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DOI：
10.1136/vr.141.12.299
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发表时间：
1997-09-20
影响因子：
2.2
通讯作者：
Jarrett, O
中科院分区：
文献类型：
--
作者：
Duthie, S;Eckersall, PD;Jarrett, O
众所周知，猫传染性腹膜炎(FIP)很难与许多其他临床症状相似的疾病区分开来，目前唯一确凿的诊断试验是活检的组织病理学检查。研究了急性时相反应物α1-酸性糖蛋白(AGP)和结合珠蛋白水平升高对该病的诊断价值，并测定了健康猫血清中AGP和结合珠蛋白的浓度，其参考范围分别为0.1~0.48g/L和0.04~3.84g/L。血清、血浆或积液标本中AGP水平高于1.5g/L对区分临床症状相似的猫和现场FIP病例有价值，并且比白蛋白/球蛋白比率更有效地区分这两组猫。FIP猫的结合珠蛋白浓度高于健康猫，但该蛋白对FIP的诊断价值不大。猫免疫缺陷病毒感染猫的血清样本也分析了这些蛋白质，它们的浓度显著升高，说明AGP和结合珠蛋白水平的升高并不是FIP的病因。
Feline infectious peritonitis (FIP) is notoriously difficult to differentiate from the many other diseases with similar clinical signs and at present the only conclusive diagnostic test is the histopathological examination of a biopsy. The potential value of raised levels of the acute phase reactants, alpha 1-acid glycoprotein (AGP) and haptoglobin in the diagnosis of the disease was investigated, The concentrations of the two proteins were determined in serum samples from healthy cats and gave reference ranges of 0.1 to 0.48 g/litre and 0.04 to 3.84 g/litre, respectively. Levels of AGP greater than 1.5 g/litre in serum, plasma or effusion samples were found to be of value in distinguishing field cases of FIP from cats with similar clinical signs and differentiated these two groups of cats more effectively than the albumin:globulin ratio. The concentration of haptoglobin was higher in cats with FIP than in the group of healthy cats, but this protein was not of value in the diagnosis of FIP. Serum samples from feline immunodeficiency virus-infected cats were also analysed for these proteins and their concentrations were significantly elevated, illustrating that raised levels of AGP and haptoglobin are not pathognomonic for FIP.