Sleep quality after initial chemotherapy for breast cancer.
Sleep quality after initial chemotherapy for breast cancer.
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DOI：
10.1007/s00520-009-0662-y
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发表时间：
2010-06
影响因子：
3.1
通讯作者：
Dudley, William N.
中科院分区：
文献类型：
--
作者：
Beck, Susan L.;Berger, Ann M.;Barsevick, Andrea M.;Wong, Bob;Stewart, Katie A.;Dudley, William N.
描述乳腺癌初始化疗前和化疗后前 3 个晚上的睡眠质量和数量。对两项独立的改善疲劳和睡眠的行为干预随机临床试验 (RCT) 的数据进行二次分析。患者来自五个州的两个综合癌症中心、三个临床癌症中心和 10 个社区诊所。参与者是接受蒽环类药物和/或环磷酰胺疗法治疗的 I-IIIA 期乳腺癌女性。分析中使用了每个随机对照试验的基线数据。 65% 的女性自我报告在化疗前一个月睡眠质量不佳，匹兹堡睡眠质量指数 (PSQI) 评分 > 5。三个晚上的体动记录仪数据显示了广泛的睡眠体验，平均每晚醒来 10 次，入睡后清醒时间（分钟）（WASO-M）平均为 61 分钟。第一晚的睡眠是最糟糕的。自我报告的睡眠不佳与通过体动记录仪获得的睡眠测量值之间没有统计学上的显着关系。基线睡眠不佳（总体 PSQI >5）的女性的身体 (MOS PCS) 和精神 (MOS MCS) 健康状况显着较低 (p<.001)。然而，PCS 和 MCS 均与聚合样本中的任何平均体动记录睡眠参数或第 1 晚参数无关。年龄的增长也与睡眠质量较差有关。很大一部分患有乳腺癌的女性在开始化疗时睡眠受到干扰，化疗后的最初几个晚上的特点是睡眠碎片化，从而扰乱了睡眠维持。干预措施应侧重于减少夜间醒来次数和持续时间的策略。需要进一步的研究来确定这段时间睡眠不佳的预测因素。
To characterize sleep quality and quantity prior to and in the first 3 nights after initial chemotherapy for breast cancer. Secondary analysis of data from two separate randomized clinical trials (RCT) of behavioral interventions to improve fatigue and sleep. Patients came from two comprehensive cancer centers, three clinical cancer centers, and 10 community clinics in five states. Participants were women with stage I-IIIA breast cancer treated with anthracycline and/or cyclophosphamide based regimens. Baseline data from each RCT were used in the analysis. Sixty-five percent of women self-reported poor sleep in the month preceding chemotherapy using the Pittsburgh Sleep Quality Index (PSQI) score >5. Three nights of actigraphy data indicated a wide range of sleep experience with an average of 10 awakenings and time (minutes) awake after sleep onset (WASO-M) averaging 61 minutes per night. The first night’s sleep was the worst. There was no statistically significant relationship between self-reported poor sleep and sleep measures obtained by actigraphy. Women with poor sleep at baseline (global PSQI >5) had significantly lower (p<.001) physical (MOS PCS) and mental (MOS MCS) health status. However neither the PCS nor MCS was associated with any of the average actigraphy sleep parameters or Night 1 parameters in the aggregated sample. Increasing age was also associated with poorer sleep. A high percent of women with breast cancer begin chemotherapy with disturbed sleep and the initial nights after chemotherapy are characterized by sleep fragmentation that disrupts sleep maintenance. Interventions should focus on strategies to decrease the number and duration of night awakenings. Further research is needed to identify predictors of poor sleep during this time.
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影响因子：
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