An Analysis of the Natural Course of Subclinical Hyperthyroidism
An Analysis of the Natural Course of Subclinical Hyperthyroidism
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DOI：
10.1097/maj.0b013e318187e16d
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发表时间：
2009-04-01
影响因子：
3.1
通讯作者：
Iglesias, Pedro
中科院分区：
文献类型：
--
作者：
Diez, Juan J.;Iglesias, Pedro
背景：我们的目的是评估亚临床甲状腺功能亢进患者队列中显性甲状腺功能亢进的发病率，并评估发展为显性甲状腺功能亢进的潜在危险因素。方法：回顾性分析75例亚临床甲状腺功能亢进患者（68例女性，平均年龄62.2±14.2岁）不同程度的血清促甲状腺素（TSH）抑制。研究了显性甲状腺功能亢进的发病率和生存时间，即不需要治疗的时间。结果：34例（45.3%）出现明显的甲状腺功能亢进，15例（20.0%）TSH恢复正常。在整个人群中，显性甲状腺功能亢进的发病率为9.69例/ 100患者-年，而在初始TSH值为0.30 ~ 0.49、0.10 ~ 0.29和0.29的受试者中，显性甲状腺功能亢进的发病率为4.12、7.41和29.63例/ 100患者-年
Background: Our aim was to evaluate the incidence rate of overt hyperthyroidism in a cohort of patients with subclinical hyperthyroidism and to assess the potential risk factors for the development of overt thyroid hyperfunction. Methods: We performed a retrospective analysis in 75 patients (68 women, mean age 62.2 +/- 14.2 years) with subclinical hyperthyroidism and different grades of serum thyrotropin (TSH) suppression. Incidence rate of overt hyperthyroidism and survival time, ie, time without requiring therapy for overt hyperthyroidism, were studied. Results: Thirty-four patients (45.3%) developed overt hyperthyroidism and 15 (20.0%) reverted to normal TSH values. The incidence rate of overt hyperthyroidism was 9.69 cases per 100 patient-year in the whole population and 4.12, 7.41, and 29.63 cases per 100 patient-year in subjects with initial TSH values of 0.30 to 0.49, 0.10 to 0.29, and