Relation of smoking and alcohol consumption to incident Alzheimer's disease.
Relation of smoking and alcohol consumption to incident Alzheimer's disease.
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吸烟和饮酒与阿尔茨海默氏病的关系。
DOI：
10.1093/oxfordjournals.aje.a116296
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发表时间：
1992
影响因子：
5
通讯作者：
Evans,DA
中科院分区：
文献类型：
--
作者：
Hebert,LE;Scherr,PA;Beckett,LA;Funkenstein,HH;Albert,MS;Chown,MJ;Evans,DA
作者在一项以社区为基础的前瞻性阿尔茨海默病研究中检查了吸烟和饮酒的影响。在1982年和1985年对马萨诸塞州东波士顿的老年人进行了两次家庭访谈，用于对阿尔茨海默病进行临床评价。共有513人接受了详细的临床评估，包括神经，神经心理和精神评估，以诊断阿尔茨海默病。在控制年龄、性别和教育的加权逻辑回归中，与从不吸烟者相比，曾经吸烟者患阿尔茨海默病的估计比值比为0.7（95%置信区间0.3-1.4）。对于40包年的吸烟，阿尔茨海默病的优势比为0.8（95%置信区间0.6-1.1）。每天摄入1盎司（30毫升）酒精与1.1的比值比（95%置信区间0.8-1.5）相关。这些结果表明，近期轻度至中度饮酒与阿尔茨海默病的发病率没有实质性关系，吸烟也不会增加该病的风险。Am J Epidemiol 1992;135：347-55。
The authors examined the effects of smoking and alcohol use in a prospective community-based study of incident Alzheimer's disease. Two in-home interviews of the total elderly population of East Boston, Massachusetts, conducted in 1982 and 1985 were used to sample individuals for clinical evaluation for Alzheimer's disease. A total of 513 persons underwent detailed clinical evaluation including neurologic, neuropsychologic, and psychiatric evaluation to diagnose Alzheimer's disease. In weighted logistic regression controlled for age, sex, and education, the estimated odds ratio of Alzheimer's disease was 0.7 (95% confidence interval 0.3–1.4) for ever smokers compared with never smokers. For 40 pack-years of smoking, the odds ratio of Alzheimer's disease was 0.8 (95% confidence interval 0.6–1.1). Consumption of 1 oz (30 ml) of alcohol per day was associated with an odds ratio of 1.1 (95% confidence interval 0.8–1.5). These results suggest that recent mild-to-moderate consumption of alcohol is not substantially related to incidence of Alzheimer's disease and that smoking does not increase risk of the disease.Am J Epidemiol1992;135:347-55.