Visual function quality of life measure changes upon conversion to neovascular age-related macular degeneration in second eyes
Visual function quality of life measure changes upon conversion to neovascular age-related macular degeneration in second eyes
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DOI：
10.1007/s11136-017-1547-z
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发表时间：
2017-08-01
影响因子：
3.5
通讯作者：
Scott, Adrienne W.
中科院分区：
文献类型：
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作者：
Paulus, Yannis M.;Jefferys, Joan L.;Scott, Adrienne W.
为了确定最初患有单侧新生血管性年龄相关性黄斑变性（AMD）的患者的第二只眼睛发生脉络膜新生血管（CNV）时生活质量指标的变化，我们分析了基线时对39项国家眼科研究所视觉功能问卷（NEI-VFQ）、36项简明健康调查表（SF-36）和医院焦虑和抑郁量表（HADS）的反应，以及在两项黄斑下手术试验中登记的92名参与者的第二眼CNV诊断之前和之后。样本量超过30的配对t检验和样本量< 30的Wilcoxon符号秩检验进行比较scoresXNV发展导致对39个NEI-VFQ项目中的20个的响应的统计学和临床显著变化，表明在平均25个月的间隔期间视觉功能下降。基线评分与CNV诊断前（平均持续时间为8.9个月）之间差异不大。子量表显示，总体视力、近距离活动、远距离活动、社交功能、角色困难、依赖性和驾驶能力在统计学上显着下降。HADS和SF-36量表的变化很小。根据患者对NEI-VFQ问卷的反应，第二只眼的CNV发展对视觉功能有显著影响。我们的研究被认为是第一个使用前瞻性收集的数据来证明AMD患者CNV发展导致的视觉相关生活质量变化的研究。
To determine changes in quality of life measures when choroidal neovascularization (CNV) developed in the second eye of patients with initially unilateral neovascular age-related macular degeneration (AMD).We analyzed responses to the 39-item National Eye Institute Visual Function Questionnaire (NEI-VFQ), 36-item Short Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale (HADS) at baseline, and prior to and following second eye CNV diagnosis in 92 participants enrolled in two Submacular Surgery Trials. Paired t-tests for sample sizes over 30 and Wilcoxon signed-rank tests for sample sizes < 30 were performed to compare scores.CNV development resulted in statistically and clinically significant changes in responses to 20 of 39 NEI-VFQ items, indicating visual function decline during a mean interval of 25 months. Little difference was noted between baseline scores and prior to CNV diagnosis, which averaged 8.9 months duration. Subscales demonstrated a statistically significant decline in general vision, near activities, distance activities, social functioning, role difficulties, dependency, and driving. There were minimal changes in the HADS and SF-36 scales.CNV development in the second eye had a dramatic effect on visual functioning based on patient responses to the NEI-VFQ questionnaire. Our investigation is believed to be the first study using data collected prospectively to demonstrate vision-related quality of life changes that resulted from development of CNV in AMD patients.