Exercise is required for visceral fat loss in postmenopausal women with type 2 diabetes
Exercise is required for visceral fat loss in postmenopausal women with type 2 diabetes
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DOI：
10.1210/jc.2004-1782
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发表时间：
2005-03-01
影响因子：
5.8
通讯作者：
Kanaley, JA
中科院分区：
文献类型：
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作者：
Giannopoulou, I;Ploutz-Synder, LL;Kanaley, JA
这项研究考察了不减肥的有氧运动、低热量高不饱和脂肪饮食以及饮食加运动(D+E)对患有2型糖尿病的肥胖绝经后女性腹部和内脏脂肪损失的影响。33名绝经后妇女(体重指数，34.6+/-1.9 kg/m(2))被分配到三种干预措施之一：低热量高不饱和脂肪饮食，单独锻炼(EX)，和D+E 14wk。干预前后测量有氧能力、身体成分、腹部脂肪分布(磁共振成像)、糖耐量和胰岛素敏感性。D组和D+E组体重(约4.5 kg)和体脂百分比(约5%)显著降低(P<；0.05)，而干预组仅降低体脂百分比(约2.3%)。D干预组和D+E干预组的总腹脂和皮下脂肪组织(SAT)减少(P<；0.05)，内脏脂肪组织(VAT)在D+E干预组和EX干预组减少，但D干预组没有。尽管没有减轻体重，但EX导致了腹脂总量、VAT和SAT的减少(P<；0.05)。腹脂和SAT的减少分别解释了空腹血糖水平变化的32.7%和9.7%，而增值税的降低解释了空腹胰岛素水平变化的15.9%(P<；0.05)。总而言之，通过D或D+E适度减肥，在绝经后2型糖尿病女性中，总腹脂、SAT和血糖状况都有类似的改善；然而，在饮食中增加运动是必要的，以减少增值税。这些数据证明了运动在女性2型糖尿病治疗中的重要性。
This study examined the effects of aerobic exercise without weight loss, a hypocaloric high monounsaturated fat diet, and diet plus exercise ( D + E) on total abdominal and visceral fat loss in obese postmenopausal women with type 2 diabetes. Thirty-three postmenopausal women ( body mass index, 34.6 +/- 1.9 kg/m(2)) were assigned to one of three interventions: a hypocaloric high monounsaturated fat diet alone, exercise alone ( EX), and D + E for 14 wk. Aerobic capacity, body composition, abdominal fat distribution ( magnetic resonance imaging), glucose tolerance, and insulin sensitivity were measured preand postintervention. Body weight ( similar to 4.5 kg) and percent body fat ( similar to 5%) were decreased ( P < 0.05) with the D and D + E intervention, whereas only percent body fat ( similar to 2.3%) decreased with EX. Total abdominal fat and sc adipose tissue ( SAT) were reduced with the D and D + E interventions ( P< 0.05), whereas visceral adipose tissue ( VAT) decreased with the D + E and EX intervention, but not with the D intervention. EX resulted in a reduction in total abdominal fat, VAT, and SAT ( P < 0.05) despite the lack of weight loss. The reductions in total abdominal fat and SAT explained 32.7% and 9.7%, respectively, of the variability in the changes in fasting glucose levels, whereas the reductions in VAT explained 15.9% of the changes in fasting insulin levels ( P < 0.05). In conclusion, modest weight loss, through either D or D + E, resulted in similar improvements in total abdominal fat, SAT, and glycemic status in postmenopausal women with type 2 diabetes; however, the addition of exercise to diet is necessary for VAT loss. These data demonstrate the importance of exercise in the treatment of women with type 2 diabetes.