Association of sex, age and education level with patient reported outcomes in atrial fibrillation
Association of sex, age and education level with patient reported outcomes in atrial fibrillation
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DOI：
10.1186/s12872-019-1059-6
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发表时间：
2019-04-05
影响因子：
2.1
通讯作者：
Nazarian, Saman
中科院分区：
文献类型：
--
作者：
Gleason, Kelly T.;Himmelfarb, Cheryl R. Dennison;Nazarian, Saman
背景：在房颤（AF）中，已知在临床结局（如卒中）方面存在性别和社会人口学差异。我们调查是否也存在差异方面的病人报告的结果。我们探讨了性别，年龄和教育水平与患者报告的结果（AF相关的生活质量，症状严重程度，情绪和功能状态）的关联：PaTH AF队列研究招募了4个学术医疗中心的AF诊断和年龄18岁的参与者（N=953）。我们采用随机效应进行纵向多元回归分析，以确定个体特征是否与患者报告的结果相关。（β-2.23，95% CI：-3.52，-0.94）和AF相关生活质量（β-4.12，95% CI：-8.10，-0.14），焦虑症状更严重（β 2.08，95% CI：0.76，3.40）、抑郁（β 1.44，95% CI：0.25，2.63）和AF（β 0.29，95% CI：0.08，0.50）。个人
Background: In atrial fibrillation (AF), there are known sex and sociodemographic disparities in clinical outcomes such as stroke. We investigate whether disparities also exist with respect to patient-reported outcomes. We explored the association of sex, age, and education level with patient-reported outcomes (AF-related quality of life, symptom severity, and emotional and functional status).Methods: The PaTH AF cohort study recruited participants (N=953) with an AF diagnosis and age18years across 4 academic medical centers. We performed longitudinal multiple regression with random effects to determine if individual characteristics were associated with patient-reported outcomes.Results: Women reported poorer functional status (beta-2.23, 95% CI: -3.52, -0.94) and AF-related quality of life (beta-4.12, 95% CI: -8.10, -0.14), and higher symptoms of anxiety (beta 2.08, 95% CI: 0.76, 3.40), depression (beta 1.44, 95% CI: 0.25, 2.63), and AF (beta 0.29, 95% CI: 0.08, 0.50). Individuals