HOX HOMEOBOX GENES AND REGIONALIZATION OF THE NERVOUS-SYSTEM
HOX HOMEOBOX GENES AND REGIONALIZATION OF THE NERVOUS-SYSTEM
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DOI：
10.1002/neu.480241006
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发表时间：
1993-10-01
期刊：
影响因子：
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通讯作者：
LUMSDEN, A
中科院分区：
文献类型：
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作者：
KRUMLAUF, R;MARSHALL, H;LUMSDEN, A
Hox家族的同源盒基因与脊椎动物胚胎的轴向模式化过程密切相关。这个家族的转录因子在进化中是广泛保守的，并且通过与果蝇的对应物HOM-C同源异型基因的类比，可以在许多胚胎系统（包括CNS）中建立区域身份中发挥作用。这些基因的表达模式与发育中的后脑中菱形和神经嵴的产生有关，并表明它们提供了一个产生组合图案机制的分子系统。通过同源重组产生的小鼠Hox突变体的分析清楚地表明，这些基因在后脑和鳃弓的正常区域化中具有重要作用，这引起了人们对它们的早期模式如何在神经系统中建立的兴趣。因此，Hox基因及其与后脑分割的关系提供了一种研究在早期神经发育中调节模式形成的级联事件的方法。(C)John Wiley & Sons，Inc.
The Hox family of homeobox-containing genes are intimately associated with the processes of axial patterning in vertebrate embryos. This family of transcription factors is widely conserved in evolution and by analogy with their Drosophila counterparts, the HOM-C homeotic genes, may play a role in establishing regional identity in a number of embryonic systems, including the CNS. The patterns of expression of these genes are linked with the generation of rhombomeres and neural crest in the developing hindbrain, and suggest that they provide a molecular system for generating a combinatorial patterning mechanism. Analysis of mouse Hox mutants generated by homologous recombination have clearly demonstrated that the genes have important roles in normal regionalisation of the hindbrain and branchial arches, and this has lead to interest in how their early patterns are established in the nervous system. The Hox genes and their relation to hindbrain segmentation therefore provide a means of examining the cascade of events which regulates pattern formation in early neural development. (C) 1993 John Wiley & Sons, Inc.