Increased number of neural progenitors in human temporal lobe epilepsy
Increased number of neural progenitors in human temporal lobe epilepsy
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DOI：
10.1016/j.nbd.2005.01.020
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发表时间：
2005-08-01
影响因子：
6.1
通讯作者：
Lerner-Natoli, M
中科院分区：
文献类型：
--
作者：
Crespel, A;Rigau, V;Lerner-Natoli, M
据报道，在内侧颞叶癫痫(MTLE)的动物模型中，神经发生增加，但新生细胞的命运尚不清楚。在这里，我们试图证明成年癫痫组织的神经发生后，海马区切除。与对照组相比，MTLE组大鼠海马区分裂标志物和神经前体细胞标志物Musashi-1的表达增加。大量Musashi-1(+)细胞明显存在于颗粒下层和室下区，这两个已知的神经起源区域，以及海马裂。Musashi-1主要由小细胞表达，主要为波形蛋白(+)或巢蛋白(+)，少数为DCX(+)或PSA-NCAM(+)，成熟神经元或星形胶质细胞的标志为阴性。其中一些存在于颗粒层、门区和CA1区，类似于啮齿类动物的异位位置。这些发现表明，神经前体细胞在慢性癫痫中增殖，并表明海马裂的行为类似于另一个神经源性区域。(C)2005 Elsevier Inc.保留所有权利。
An increased neurogenesis is reported in animal models of mesial temporal lobe epilepsy (MTLE) but the fate of newborn cells is unknown. Here, we attempted to demonstrate neurogenesis in adult epileptic tissue obtained after hippocampectomy. MTLE hippocampi showed increased expression of division markers and of Musashi-1, a marker of neural progenitors, compared to control hippocampi. Large quantities of Musashi-1(+) cells were obvious in the subgranular layer and the subventricular zone, both known neurogenic areas, and in the fissura hippocampi. Musashi-1 was expressed by small cells that were mainly vimentin(+) or nestin(+), rarely Dcx(+) or PSA-NCAM(+) and negative for markers of mature neurons or astrocytes. Some of them are present in the granular layer, the hilus, and CA1 area resembling the ectopic positions described in rodents. These findings demonstrate that neural progenitors proliferate in chronic epilepsy and suggest that the fissura hippocampi behaves like another neurogenic area. (c) 2005 Elsevier Inc. All rights reserved.