A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: The Hisayama study
A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: The Hisayama study
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DOI：
10.1002/ijc.21822
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发表时间：
2006-07-01
影响因子：
6.4
通讯作者：
Iida, Mitsuo
中科院分区：
文献类型：
--
作者：
Shikata, Kentaro;Kiyohara, Yutaka;Iida, Mitsuo
关于食盐摄入量与胃癌发生之间关系的前瞻性研究结果仍存在争议。为了在一项针对普通人群的队列研究中研究这一问题，2,476名40岁或以上的受试者根据每日盐摄入量分为4组：即每天< 10.0、10.0-12.9、13.0-15.9和>= 16.0，并前瞻性随访14年。在随访期间，93例受试者发生胃癌。第二组至第四组的年龄和性别校正发生率显著高于第一组（第二组的年龄和性别校正风险比[95%置信区间]为2.42 [1.24-4.71];第三组为2.10 [1.03-4.30];第四组为2.98 [1.5-3-5.82]）。即使调整了其他混杂因素，如年龄、性别、幽门螺杆菌感染、萎缩性胃炎、消化性溃疡病史、癌症家族史、体重指数、糖尿病、总胆固醇、体力活动、酒精摄入、吸烟习惯和其他饮食因素，这种相关性也基本保持不变。在分层分析中，仅在同时患有幽门螺杆菌感染和萎缩性胃炎的受试者中观察到盐与癌症的显著相关性（年龄和性别校正的风险比，2.87 [1.14-7.24]）。我们的研究结果表明，高饮食盐摄入量是胃癌的一个重要的危险因素，而且，这种关联被认为是强幽门螺杆菌感染与萎缩性胃炎的存在。(c)2006 Wiley-Liss，Inc.
The results of prospective studies of the association between dietary salt intake and gastric cancer occurrence remain controversial. To examine this issue in a cohort study of a general population, 2,476 subjects aged 40 years or older were stratified into 4 groups according to the amount of daily salt intake: namely, < 10.0, 10.0-12.9, 13.0-15.9, and >= 16.0 per day and were followed up prospectively for 14 years. During the follow-up period, 93 subjects developed gastric cancer. The age- and sex-adjusted incidence was significantly higher in the second to fourth groups than in the first group (age- and sex-adjusted hazard ratio [95% confidence interval], 2.42 [1.24-4.71] for the second group; 2.10 [1.03-4.30] for the third group; 2.98 [1.5-3-5.82] for the fourth group). This association remained substantially unchanged even after adjusting for other confounding factors such as age, sex, Helicobacter pylori infection, atrophic gastritis, medical history of peptic ulcer, family history of cancer, body mass index, diabetes, total cholesterol, physical activity, alcohol intake, smoking habit and other dietary factors. In the stratified analysis, a significant salt-cancer association was observed only in subjects who had both Helicobacter pylori infection and atrophic gastritis (age- and sex-adjusted hazard ratio, 2.87 [1.14-7.24]). Our findings suggest that high dietary salt intake is a significant risk factor for gastric cancer; moreover, this association was found to be strong in the presence of Helicobacter pylori infection with atrophic gastritis. (c) 2006 Wiley-Liss, Inc.