Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
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DOI：
10.1038/387049a0
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发表时间：
1997-05-01
期刊：
影响因子：
64.8
通讯作者：
DePinho, RA
中科院分区：
文献类型：
--
作者：
Alland, L;Muhle, R;DePinho, RA
正常哺乳动物的生长和发育高度依赖于Myo家族转录因子的表达和活性的调节。Mxi 1介导的Myc活性抑制需要与哺乳动物Sin 3A或Sin 3B蛋白相互作用，这些蛋白被认为是其他共阻遏因子的支架。两个这样的Sin 3相关因子，核受体辅阻遏物（N-CoR）和组蛋白去乙酰化酶（HD 1）的鉴定，提供了Mxi 1/Sin 3诱导的转录抑制和肿瘤抑制的基础。
Normal mammalian growth and development ave highly dependent on the regulation of the expression and activity of the Myo family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.