MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia
MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia
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DOI：
10.1097/00001756-199802160-00013
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发表时间：
1998-02-16
期刊：
影响因子：
1.7
通讯作者：
Atlas, SW
中科院分区：
文献类型：
--
作者：
Buchsbaum, MS;Tang, CY;Atlas, SW
额-纹状体-丘脑回路紊乱已被提出与精神分裂症有关，但这一概念主要基于精神药理学的间接证据和与动物研究的类比。扩散张量成像是一种新的MRI技术，可以直接评估从前额皮质延伸到纹状体的大轴突团块，用于研究白质轴突束。对5名精神分裂症患者和6名年龄和性别匹配的正常对照者进行了扩散张量图像、高分辨率结构MRI和正电子发射断层扫描。统计概率图显示，精神分裂症患者前额叶皮层白质弥散各向异性明显低于正常对照组。共同注册的PET扫描显示，患者前额叶皮层和纹状体代谢率之间的相关系数明显低于对照组。这两项发现为精神分裂症患者额纹状体连通性下降提供了趋同证据。(C) 1998快速科学有限公司
A disturbance in the frontal-striatal-thalamic circuitry has been proposed for schizophrenia, but this concept has been based primarily on indirect evidence from psychopharmacology and analogies with animal research. Diffusion tensor imaging, a new MRI technique that permits direct assessment of the large axon masses stretching from the prefrontal cortex to the striatum, was used to study white matter axon bundles. Diffusion tensor images, high-resolution structural MRI and positron emission tomography scans with 18-fluorodexoyglucose were obtained on five patients with schizophrenia and six age-and sex-matched normal controls. Significantly lower diffusion anisotropy in the white matter of the prefrontal cortex in schizophrenic patients than in normal controls was observed in statistical probability maps. Co-registered PET scans revealed significantly lower correlation coefficients between metabolic rates in the prefrontal cortex and striatum in patients than in controls. These twin findings provide convergent evidence for diminished fronto-striatal connectivity in schizophrenia. (C) 1998 Rapid Science Ltd.