IS TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE A SOMATIC MUTAGEN IN LYMPHOCYTES
IS TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE A SOMATIC MUTAGEN IN LYMPHOCYTES
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DOI：
10.1038/248409a0
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发表时间：
1974-01-01
期刊：
影响因子：
64.8
通讯作者：
BALTIMORE, D
中科院分区：
文献类型：
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作者：
BALTIMORE, D
Bollum 和他的同事在小牛胸腺中鉴定出了一种能够将脱氧核糖核苷酸添加到 DNA 引物末端的酶，并将其命名为末端脱氧核苷酸转移酶 1-4。 Chang5 指出，这种酶是胸腺细胞的特殊成分，在几种动物物种的任何其他器官中都不存在。该酶位于胸腺的淋巴细胞部分（Silverstone、Parkman、Mcaffrey 和 Baltimore，未发表的结果）。最近，我们在急性淋巴细胞白血病患者的循环淋巴母细胞中发现了一种具有末端转移酶特性的酶（参考文献 6 以及 McCaffrey、Harrison 和 Baltimore，未发表的结果）。
AN enzyme able to add deoxyribonucleotides to the ends of DNA primers has been identified in calf thymus by Bollum and his colleagues and named terminal deoxynucleotidyl transferase1–4. Chang5has indicated that the enzyme is a specialised constituent of thymus cells and is not present in any other organ of several animal species. The enzyme is located in the lymphocyte fraction of the thymus (Silverstone, Parkman, McCaffrey and Baltimore, unpublished results). Recently, we found an enzyme with the properties of a terminal transferase in circulating lymphoblasts of patients with acute lymphoblastic leukaemia (ref. 6 and McCaffrey, Harrison, and Baltimore, unpublished results).