EFFECT OF EXERCISE TRAINING ON TISSUE VITAMIN-E AND UBIQUINONE CONTENT
EFFECT OF EXERCISE TRAINING ON TISSUE VITAMIN-E AND UBIQUINONE CONTENT
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DOI：
10.1152/jappl.1987.63.4.1638
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发表时间：
1987-10-01
影响因子：
3.3
通讯作者：
PACKER, L
中科院分区：
文献类型：
--
作者：
GOHIL, K;ROTHFUSS, L;PACKER, L
耐力运动训练导致红色股四头肌、比目鱼肌和脂肪组织的单醌含量和细胞色素c还原酶活性适应性增加，但心肌或白色股四头肌没有。这些发现与众所周知的骨骼肌线粒体对耐力训练的积极适应一致。然而，组织中维生素E的含量并没有随之增加，这表明线粒体含量有所增加。由于泛醌位于线粒体内膜，而维生素 E 的主要库也与线粒体膜相关，因此结果表明，训练会导致增殖的肌肉线粒体膜中维生素 E 浓度大幅下降，从而耗尽肌肉线粒体的主要脂质抗氧化剂。由于维生素 E 是主要的细胞、脂溶性、断链抗氧化剂，这些发现表明运动动物组织中的自由基反应增加。
Endurance exercise training led to an adaptive increase in the uniquinone content and cytochrome c reductase activity of red quadriceps and soleus muscles and adipose tissues, but not of cardiac or white quadriceps muscle. These findings are consistent with the well-known positive adaptation of skeletal muscle mitochondria to endurance training. However, there was no concomitant increase in the vitamin E content of tissues, which showed an increase in mitochondrial content. Since ubiquinone is located in the mitochondrial inner membrane and the major pool of vitamin E is also associated with mitochondrial membranes, the results suggest that training causes a substantial decrease in vitamin E concentration in the proliferating muscle mitochondrial membranes, thus depleting muscle mitochondria of their major lipid antioxidant. Since vitamin E is the major cellular, lipid-soluble, chain-breaking antioxidant, these findings indicate increased free radical reactions in the tissues of exercising animals.