Prevalence of Vertebral Fractures in Children with Chronic Rheumatic Diseases at Risk for Osteopenia
Prevalence of Vertebral Fractures in Children with Chronic Rheumatic Diseases at Risk for Osteopenia
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DOI：
10.1016/j.jpeds.2008.09.023
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发表时间：
2009-03-01
影响因子：
5.1
通讯作者：
Rodd, Celia
中科院分区：
文献类型：
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作者：
Nakhla, Meranda;Scuccimarri, Rosie;Rodd, Celia
研究设计我们对蒙特利尔儿童医院的慢性风湿性疾病患者进行了一项横断面研究，以确定骨质减少风险的慢性风湿性疾病儿童队列中椎骨骨折的患病率和风险因素。（22名男孩，68名女孩），10名男孩和7名女孩（19%）被发现有椎骨骨折。这17名儿童共发生6次骨折，共50次骨折，平均每个受影响的儿童发生2.9次骨折。上胸椎（T5-8）骨折占55%。只有56%的骨折有症状。通过多变量回归分析，我们发现男性（P <0.01）、体重指数z评分（P <0.02）、中等累积糖皮质激素剂量（P <0.01）是椎骨骨折数量的重要预测因素。我们的队列中有19%的人有脊椎骨折。发生椎骨骨折的重要危险因素包括男性和累积糖皮质激素剂量。更好地了解这一人群的问题程度将使我们能够进一步完善这些患者的筛查指南和治疗。（J Pediatr 2009，154：438-43）
Objectives To determine the prevalence of and the risk factors for vertebral fractures in a cohort of children with chronic rheumatic diseases considered at risk for osteopenia.Study design We conducted a cross-sectional study of patients with chronic rheumatic diseases at the Montreal Children's Hospital.Results Of the 90 study participants (22 boys, 68 girls), 10 boys and 7 girls (19%) were found to have vertebral fractures. These 17 children had 6 total of 50 fractures, an average of 2.9 per affected child. Fractures in die upper thoracic region (T5-8) accounted for 55%. Only 56% of all fractures were symptomatic. With multivariate regression, we identified male sex (P < .01), body mass index z-score (P < .02), mid cumulative glucocorticoid dose (P < .01) as significant predictors of the number of vertebral fractures.Conclusions Our study examined the prevalence of vertebral fractures in a high-risk pediatric population. Nineteen percent of our cohort had vertebral fractures. Significant risk factors for the development of vertebral fractures include male sex and cumulative glucocorticoid dose. Better understanding of the extent of the problem in this population will allow, us to further refine screening guidelines and treatment in these patients. (J Pediatr 2009,154:438-43)