Olfactory recognition memory in mice depends on task parameters.
Olfactory recognition memory in mice depends on task parameters.
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小鼠的嗅觉识别记忆取决于任务参数。
DOI：
10.1037/bne0000421
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发表时间：
2020
影响因子：
1.9
通讯作者：
Linster, Christiane
中科院分区：
文献类型：
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作者：
Buseck, Alison;McPherson, Katherine;Linster, Christiane
我们使用一个简单的两次试验气味识别范式来测试成年小鼠的记忆持续时间，广度和特异性。我们的范例允许小鼠在一次试验中编码和/或回忆多种气味，并且不需要训练或食物/水剥夺。我们表明，这种模式可以用于编码和/或测试多种气味在单一的试验，导致更短的行为测试。使用这个简单的范例，我们表明，小鼠可以记住一种气味长达10，但不超过15分钟，两种气味长达5分钟。小鼠不能记住3种气味在任何延迟测试。我们还表明，特异性的编码气味减少延迟增加。我们的研究结果是很重要的设置基线水平的测试中的记忆参数预计将被调制的实验。
We use a simple two-trial odor recognition paradigm to test memory duration, span, and specificity in adult mice. Our paradigm allows mice to encode and/or recall multiple odors in one trial and necessitates no training or food/water deprivation. We show that this paradigm can be used for encoding and/or testing of multiple odors in single trials, leading to shorter behavioral testing. Using this simple paradigm, we show that mice can remember a single odor for up to 10 but no more than 15 min and two odors for up to 5 min. Mice could not remember 3 odors at any delays tested here. We also show that specificity for the encoded odor decreases as delay increases. Our results are important for setting baseline levels of testing for experiments in which memory parameters are expected to be modulated.