Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.
Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.
复制标题
组织集成氧传感器：连续跟踪组织缺氧。
DOI：
10.1007/978-3-319-55231-6_49
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发表时间：
2017
影响因子：
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通讯作者：
Helton,KristenL
中科院分区：
文献类型：
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作者：
Wisniewski,NatalieA;Nichols,ScottP;Gamsey,SoyaJ;Pullins,Steve;Au-Yeung,KitY;Klitzman,Bruce;Helton,KristenL
我们描述了一种简单的方法，跟踪氧气实时注射，组织集成微传感器。传感器体积小（500 μm × 500 μm × 5 mm）、柔软、灵活、组织样、生物相容性水凝胶，已被证明可以克服异物反应，实现长期传感。这些传感器被设计成在氧气或其他分析物存在的情况下改变发光，并在体内发挥作用数月至数年。单次注射后，使用手持式或可穿戴式蓝牙光学读取器进行无创监测，可实现间歇或连续测量。在高海拔、运动生理学、血管疾病、中风、肿瘤和其他疾病状态中的应用的概念证明已经在小鼠、大鼠和猪模型中显示。迄今为止，已经在人类身上研究了90多种传感器。这些新型的组织集成传感器可以实时了解组织氧波动，用于研究和临床应用。
We describe a simple method of tracking oxygen in real-time with injectable, tissue-integrating microsensors. The sensors are small (500 μm × 500 μm × 5 mm), soft, flexible, tissue-like, biocompatible hydrogel s that have been shown to overcome the foreign body response for long-term sensing. The sensors are engineered to change luminescence in the presence of oxygen or other analytes and function for months to years in the body. A single injection followed by non-invasive monitoring with a hand-held or wearable Bluetooth optical reader enables intermittent or continuous measurements. Proof of concept for applications in high altitude, exercise physiology, vascular disease, stroke, tumors, and other disease states have been shown in mouse, rat and porcine models. Over 90 sensors have been studied to date in humans. These novel tissue-integrating sensors yield real-time insights in tissue oxygen fluctuations for research and clinical applications.