POLYAMINE COMPARTMENTALIZATION IN VARIOUS HUMAN DISEASE STATES
POLYAMINE COMPARTMENTALIZATION IN VARIOUS HUMAN DISEASE STATES
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DOI：
10.1016/0009-8981(78)90019-0
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发表时间：
1978-01-01
影响因子：
5
通讯作者：
RENNERT, OM
中科院分区：
文献类型：
--
作者：
COOPER, KD;SHUKLA, JB;RENNERT, OM
将全血分离成红细胞、单核白细胞、多形核白细胞、血小板和血浆制剂。分析每种制剂中多胺腐胺、亚精胺和精胺的浓度。这项研究在 17 名对照者、14 名银屑病患者、4 名遗传性椭圆形红细胞增多症患者、2 名慢性淋巴细胞白血病患者以及各 1 名肺癌、非霍奇金淋巴瘤、镰状细胞性贫血伴轻度银屑病和早衰症患者中进行。在血液多胺水平升高的患者中，红细胞吸收相对常见，精胺/亚精胺比率可用于定位异常和表征多胺改变的性质。相对于对照组，增殖状态与精胺/亚精胺比率升高相关。这种关系在遗传性椭圆红细胞增多症和镰状细胞性贫血等红细胞病中则相反。
Whole blood was separated into preparations of erythrocytes, mononuclear leukocytes, polymorphonuclear leukocytes, platelets and plasma. Each preparation was analyzed for the concentration of the polyamines putrescine, spermidine and spermine. This was done in 17 controls, 14 patients with psoriasis, 4 patients with hereditary elliptocytosis, 2 patients with chronic lymphocytic leukemia and 1 patient each with lung cancer, non-Hodgkin''s lymphoma, sickle cell anemia with mild psoriasis, and progeria. In patients with elevated blood polyamine levels, absorption onto erythrocytes was relatively common, and the spermine/spermidine ratio was useful in localizing abnormalities and characterizing the nature of the polyamine alteration. Proliferative states were associated with elevated spermine/spermidine ratios relative to controls; this relationship was reversed in erythropathies such as hereditary elliptocytosis and sickle cell anemia.