Mucin distribution in bronchiolar adenoma/ciliated muconodular papillary tumor reveals organoid differentiation simulating the normal lung
Mucin distribution in bronchiolar adenoma/ciliated muconodular papillary tumor reveals organoid differentiation simulating the normal lung
复制标题
细支气管腺瘤/纤毛粘液结节性乳头状瘤中的粘蛋白分布揭示了模拟正常肺的类器官分化
DOI：
10.1111/pin.13220
复制
发表时间：
2022
影响因子：
2.2
通讯作者：
Nakayama J
中科院分区：
文献类型：
--
作者：
Matoba H;Ikeyama M;Kobayashi N;Takemura H;Hanaoka T;Sato Y;Nakayama J
细支气管腺瘤/纤毛黏结状乳头状肿瘤是一种表现出不同程度的近端和远端细支气管分化的肺肿瘤。在这里，我们评估了MUC5AC和MUC5B在细支气管腺瘤/纤毛粘液结节乳头状瘤中的分布，并与正常呼吸道中的分布进行了比较。在正常呼吸道中，MUC5AC主要分布于大支气管，MUC5B分布于支气管、细支气管和粘膜下腺体。在细支气管腺瘤/纤毛粘膜结节状乳头状瘤中，MUC5AC主要分布在大气隙的管腔细胞中，MUC5B除分布在大气隙外，还分布在小气隙的管腔细胞和粘液腺中，无论远端分化还是近端分化。特别地，MUC5B分布在正常呼吸道和细支气管腺瘤/纤毛粘膜乳头状瘤的非粘液俱乐部细胞和纤毛细胞中。结果表明，MUC5AC和MUC5B在细支气管腺瘤/纤毛粘膜结节状乳头状瘤中的分布与正常呼吸道相似，提示类似于正常肺的类器官分化。
Bronchiolar adenoma/ciliated muconodular papillary tumor is a lung neoplasm exhibiting various degrees of proximal and distal bronchiolar differentiation. Here, we evaluated distribution of MUC5AC and MUC5B in bronchiolar adenoma/ciliated muconodular papillary tumor for comparison with that seen in normal respiratory tract. In normal respiratory tract, MUC5AC was mainly distributed in large bronchi, while MUC5B was distributed in bronchi, bronchioles, and submucosal glands. In bronchiolar adenoma/ciliated muconodular papillary tumor, MUC5AC was primarily distributed in luminal cells of large airspaces, and MUC5B was distributed in luminal cells of small airspaces and mucinous glands, in addition to large airspaces, regardless of distal or proximal differentiation. In particular, MUC5B was distributed in non‐mucinous club and ciliated cells in both the normal respiratory tract and bronchiolar adenoma/ciliated muconodular papillary tumor. These results indicate that MUC5AC and MUC5B distribution in bronchiolar adenoma/ciliated muconodular papillary tumor is similar to that seen in normal respiratory tract, suggestive of organoid differentiation simulating the normal lung.