Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease.
Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease.
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DOI：
10.2174/15701611113119990014
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发表时间：
2015
影响因子：
4.5
通讯作者：
Leeper NJ
中科院分区：
文献类型：
--
作者：
Hamburg NM;Leeper NJ
外周动脉疾病（PAD）可导致下肢缺血。改善PAD患者临床症状的治疗方式有限。越来越多的证据表明，microrna与PAD中控制疾病表达的关键过程有关，包括血管生成、内皮功能、炎症、血管再生、血管平滑肌细胞功能、再狭窄和线粒体功能。microrna已经在循环中被发现，并可能作为PAD的新的生物标志物。本文综述了microRNA对PAD疾病发展关键途径的潜在贡献，可能导致基于microRNA的诊断和治疗方法。
Peripheral artery disease (PAD) produces significant disability attributable to lower extremity ischemia. Limited treatment modalities exist to ameliorate clinical symptoms in patients with PAD. Growing evidence links microRNAs to key processes that govern disease expression in PAD including angiogenesis, endothelial function, inflammation, vascular regeneration, vascular smooth muscle cell function, restenosis, and mitochondrial function. MicroRNAs have been identified in circulation and may serve as novel biomarkers in PAD. This article reviews the potential contribution of microRNA to key pathways of disease development in PAD that may lead to microRNA-based diagnostic and therapeutic approaches.