The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans
The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans
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DOI：
10.1002/hup.611
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发表时间：
2004-10-01
影响因子：
1.7
通讯作者：
Nathan, PJ
中科院分区：
文献类型：
--
作者：
Lu, K;Gray, MA;Nathan, PJ
L-茶氨酸（δ-谷氨酰乙基酰胺）是绿茶中常见的主要氨基酸之一，历史上一直被用作放松剂。目前的研究使用预期焦虑（AA）模型，检查了 L-茶氨酸与标准苯二氮卓类抗焦虑药、阿普唑啉和安慰剂对健康人类受试者焦虑行为测量的急性影响。十六名健康志愿者在双盲安慰剂对照重复测量设计中接受阿普唑啉（1 毫克）、L-茶氨酸（200 毫克）或安慰剂。在放松和实验诱导的焦虑条件下评估阿普唑仑和 L-茶氨酸的急性作用。在给药前和给药后的两种任务条件下获得焦虑的主观自我报告，包括 BAI、VAMS、STAI 状态焦虑。结果表明，在基线条件下，L-茶氨酸对 VAMS 的平静困扰子量表具有放松作用。与安慰剂相比，阿普唑仑在放松状态下的任何测量中均未产生任何抗焦虑作用。 L-茶氨酸和阿普扎仑在实验诱发的焦虑状态下均没有任何显着的抗焦虑作用。研究结果表明，虽然 L-茶氨酸在静息条件下可能具有一些放松作用，但在 AA 模型中焦虑增加的情况下，L-茶氨酸和阿普唑仑都没有表现出任何急性抗焦虑作用。版权所有 (C) 2004 John Wiley Sons, Ltd.
L-Theanine (delta-glutamylethylamide) is one of the predominant amino acids ordinarily found in green tea, and historically has been used as a relaxing agent. The current study examined the acute effects Of L-theanine in comparison with a standard benzodiazepine anxiolytic, alprazolain and placebo on behavioural measures of anxiety in healthy human subjects using the model of anticipatory anxiety (AA). Sixteen healthy volunteers received alprazolain (1 mg), L-theanine (200 mg) or placebo in a double-blind placebo-controlled repeated measures design. The acute effects of alprazolam and L-theanine were assessed under a relaxed and experimentally induced anxiety condition. Subjective self-reports of anxiety including BAI, VAMS, STAI state anxiety, were obtained during both task conditions at pre- and post-drug administrations. The results showed some evidence for relaxing effects Of L-theanine during the baseline condition on the tranquil-troubled subscale of the VAMS. Alprazolam did not exert any anxiolytic effects in comparison with the placebo on any of the measures during the relaxed state. Neither L-theanine nor alprazalam had any significant anxiolytic effects during the experimentally induced anxiety state. The findings suggest that while L-theanine may have some relaxing effects under resting conditions, neither L-theanine not alprazolam demonstrate any acute anxiolytic effects under conditions of increased anxiety in the AA model. Copyright (C) 2004 John Wiley Sons, Ltd.