Very low gene duplication rate in the yeast genome
Very low gene duplication rate in the yeast genome
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DOI：
10.1126/science.1102033
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发表时间：
2004-11-19
期刊：
影响因子：
56.9
通讯作者：
Innan, H
中科院分区：
文献类型：
--
作者：
Gao, LZ;Innan, H
酵母基因组中的基因重复率是在不假设分子钟模型类似于每十亿年每个基因 0.01 到 0.06 的情况下估计的；该速率比之前基于分子钟模型的估计值低两个数量级。这种差异可以通过重复基因之间的基因转换进行广泛的协调进化来解释，这违反了重复基因分析中分子钟的假设。协同进化周期的平均长度和基因转换率估计分别约为2500万年和突变率的28倍。
The gene duplication rate in the yeast genome is estimated without assuming the molecular clock model to be similar to0.01 to 0.06 per gene per billion years; this rate is two orders of magnitude lower than a previous estimate based on the molecular clock model. This difference is explained by extensive concerted evolution via gene conversion between duplicated genes, which violates the assumption of the molecular clock in the analyses of duplicated genes. The average length of the period of concerted evolution and the gene conversion rate are estimated to be similar to25 million years and similar to28 times the mutation rate, respectively.