Evoked electromyography to rocuronium in orbicularis oris and gastrocnemius in facial nerve injury in rabbits
Evoked electromyography to rocuronium in orbicularis oris and gastrocnemius in facial nerve injury in rabbits
复制标题
罗库溴铵口轮匝肌和腓肠肌诱发肌电图对家兔面神经损伤的影响
DOI：
10.1016/j.jss.2013.05.087
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发表时间：
2013-11-01
影响因子：
2.2
通讯作者：
Li, Shitong
中科院分区：
文献类型：
--
作者：
Xing, Yian;Chen, Lianhua;Li, Shitong
背景：面神经支配的肌肉对肌肉松弛剂的敏感性不同于躯体神经支配的肌肉，特别是在面神经损伤的情况下。我们比较了兔面神经分级损伤模型中口轮匝肌和腓肠肌在使用和不使用非去极化肌肉松弛剂时的诱发肌电反应。方法：观察罗库溴铵对成年家兔面神经不同程度挤压伤后7 ~ 42 d口轮匝肌和腓肠肌肌电反应及抑制作用的差异。结果：口轮匝肌的基线肌电图明显小于腓肠肌。腓肠肌对罗库溴铵的敏感性高于面肌（P < 0.05）。罗库溴铵存在时口轮匝肌的基线眼电图和眼电图波幅与面神经损伤程度呈负相关，但与罗库溴铵敏感性无显著相关性。罗库溴铵在腓肠肌和正常或受损面部肌肉的起效时间和恢复时间无显著差异。结论：体神经支配的肌肉对罗库溴铵的敏感性高于面神经支配的肌肉，面神经损伤虽降低了肌电反应，但对罗库溴铵的敏感性未见改变。局部神经肌肉阻滞可能是一种适合的技术进行麻醉和手术时，需要眼电监测，以保持和保护面神经安全。如果有先前存在的面神经损伤的风险，应格外小心。(C) 2013爱思唯尔公司版权所有。
Background: Muscles innervated by the facial nerve show different sensitivities to muscle relaxants than muscles innervated by somatic nerves, especially in the presence of facial nerve injury. We compared the evoked electromyography (EEMG) response of orbicularis oris and gastrocnemius in with and without a non-depolarizing muscle relaxant in a rabbit model of graded facial nerve injury.Methods: Differences in EEMG response and inhibition by rocuronium were measured in the orbicularis oris and gastrocnemius muscles 7 to 42 d after different levels of facial nerve crush injuries in adult rabbits.Results: Baseline EEMG of orbicularis oris was significantly smaller than those of the gastrocnemius. Gastrocnemius was more sensitive to rocuronium than the facial muscles (P < 0.05). Baseline EEMG and EEMG amplitude of orbicularis oris in the presence of rocuronium was negatively correlated with the magnitude of facial nerve injury but the sensitivity to rocuronium was not. No significant difference was found in the onset time and the recovery time of rocuronium among gastrocnemius and normal or damaged facial muscles.Conclusions: Muscles innervated by somatic nerves are more sensitive to rocuronium than those innervated by the facial nerve, but while facial nerve injury reduced EEMG responses, the sensitivity to rocuronium is not altered. Partial neuromuscular blockade may be a suitable technique for conducting anesthesia and surgery safely when EEMG monitoring is needed to preserve and protect the facial nerve. Additional caution should be used if there is a risk of preexisting facial nerve injury. (C) 2013 Elsevier Inc. All rights reserved.