Direct demonstration of reduction of the output of the human motor cortex induced by a fatiguing muscle contraction
Direct demonstration of reduction of the output of the human motor cortex induced by a fatiguing muscle contraction
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DOI：
10.1007/s00221-003-1408-6
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发表时间：
2003-04-01
影响因子：
2
通讯作者：
Rothwell, JC
中科院分区：
文献类型：
--
作者：
Di Lazzaro, V;Oliviero, A;Rothwell, JC
短暂的肌肉强收缩抑制了对侧运动皮层经颅磁刺激（TMS）在放松肌肉中诱发的EMG反应幅度。在这里，我们调查这一现象更详细地通过记录TMS引起的下行运动凌空从电极在颈部硬膜外腔的三个清醒的患者植入慢性电刺激器控制疼痛。我们证实，疲劳抑制由TMS诱发的I波。此外，两名患者的D波被抑制，这表明轴突兴奋性也可能受到一段时间的强烈肌肉收缩的影响。
A brief period of strong muscle contraction suppresses the amplitude of EMG responses evoked in relaxed muscle by transcranial magnetic stimulation (TMS) of the contralateral motor cortex. Here we investigate this phenomenon in more detail by recording the descending motor volleys evoked by TMS from electrodes in the cervical epidural space of three conscious patients implanted with chronic electrical stimulators for control of pain. We confirm that fatigue suppresses I waves evoked by TMS. In addition, D waves were suppressed in two of the patients, suggesting that axonal excitability might also be compromised by a period of intense muscle contraction.