Macrophage stimulation and the inflammatory response to asbestos.
Macrophage stimulation and the inflammatory response to asbestos.
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DOI：
10.1289/ehp.803469
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发表时间：
1980-02
影响因子：
10.4
通讯作者：
Hamilton, J A
中科院分区：
文献类型：
--
作者：
Hamilton, J A
将温石棉纤维注射到小鼠的腹膜腔中引起细胞渗出物。与腹膜巨噬细胞群相比，渗出液中的巨噬细胞产生高水平的中性蛋白酶、纤溶酶原激活物。相反，两种巨噬细胞类型的溶菌酶和两种溶酶体酶的水平是相同的。石棉诱导的巨噬细胞产生纤溶酶原激活物似乎是从最近分裂的前体中产生的。低浓度抗炎糖皮质激素抑制巨噬细胞纤溶酶原激活物合成。初步实验表明，不同石棉类型均能引起皮肤充血，缩短血浆部分凝血活酶时间，并产生激肽释放。这些观察结果可能是相互关联的，并建议作为代表主机石棉暴露的炎症反应的某些方面。
Chrysotile fibers injected into the peritoneal cavity of mice elicit a cellular exudate. Macrophages appearing in this exudate produce high levels of the neutral protease, plasminogen activator, when compared with the resident peritoneal macrophage population. In contrast, the levels of lysozyme and two lysosomal enzymes are the same for the two macrophage types. The asbestos-induced macrophages producing the plasminogen activator appear to have descended from recently divided precursors. Low concentrations of anti-inflammatory glucocorticoids inhibit macrophage plasminogen activator synthesis. Preliminary experiments indicate that different asbestos types induce hyperemia in skin, and also shorten the partial thromboplastin time of plasma and generate the release of kinins. These observations could be interrelated and are suggested as representing some aspects of the inflammatory response of the host to asbestos exposure.