Nano-Drug Design Based on the Physiological Properties of Glutathione.
Nano-Drug Design Based on the Physiological Properties of Glutathione.
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基于谷胱甘肽生理特性的纳米药物设计。
DOI：
10.3390/molecules26185567
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发表时间：
2021-09-13
期刊：
影响因子：
--
通讯作者：
Qi J
中科院分区：
文献类型：
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作者：
Li W;Li M;Qi J
谷胱甘肽（GSH）作为一种重要的抗氧化剂，参与并调节机体的重要生理功能。GSH具有抗氧化、解毒、抗衰老、增强免疫力和抗肿瘤等作用。本文基于GSH在不同疾病中的生理特性，主要包括GSH的强还原性、肿瘤细胞中GSH含量高、GSSH还原为GSH时NADPH耗竭等，广泛报道了各种纳米药物在糖尿病、癌症、神经系统疾病、荧光探针、成像、食品等方面的设计原理、效果和潜在问题。这些研究充分利用了GSH的生理和病理价值，开发了与GSH相关的纳米药物的优良设计方法，对于GSH参与或应答的相关疾病研究显示出重要的科学意义和突出的应用价值。
Glutathione (GSH) is involved in and regulates important physiological functions of the body as an essential antioxidant. GSH plays an important role in anti-oxidation, detoxification, anti-aging, enhancing immunity and anti-tumor activity. Herein, based on the physiological properties of GSH in different diseases, mainly including the strong reducibility of GSH, high GSH content in tumor cells, and the NADPH depletion when GSSH is reduced to GSH, we extensively report the design principles, effect, and potential problems of various nano-drugs in diabetes, cancer, nervous system diseases, fluorescent probes, imaging, and food. These studies make full use of the physiological and pathological value of GSH and develop excellent design methods of nano-drugs related to GSH, which shows important scientific significance and prominent application value for the related diseases research that GSH participates in or responds to.