Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011-2012.
Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011-2012.
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DOI：
10.1186/1476-069x-13-87
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发表时间：
2014-10-24
期刊：
影响因子：
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通讯作者：
Bouchard MF
中科院分区：
文献类型：
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作者：
Oulhote Y;Mergler D;Bouchard MF
锰是一种必需元素，但过量的锰暴露具有神经毒性作用。检测一般人群的血锰水平，包括性别、年龄、种族/民族、妊娠和月经状况，以及血液中的微量元素水平。我们使用的数据来自国家健康和营养调查，这是一项针对美国居民的全国性调查（n = 7720名参与者，年龄1至80岁）。一般线性模型和广义加性模型被用来检查血锰浓度和参与者的特征之间的关联，占复杂的调查设计。血锰水平范围为1.6至62.5 μg/L，女性和男性的算术平均值分别为10.6和9.2 μg/L。以下特征与较高的血锰水平显著相关：女性、年轻、亚洲血统和怀孕。此外，血锰水平与镉、铁、铅和汞水平之间存在非线性关系。在女性中观察到的较高的血锰水平表明，在锰的调节方面存在与性别相关的代谢差异，孕妇中锰水平的升高表明锰在生殖中的重要作用。本研究支持需要考虑到年龄和性别相关的差异，血锰水平，以及怀孕状态时，检查锰的必要性或毒性。
Manganese is an essential element, but excessive manganese exposure has neurotoxic effects. To examine blood manganese levels in the general population with respect to sex, age, race/ethnicity, pregnancy and menauposal status, as well as levels of trace elements in blood. We used data from the National Health and Nutrition Examination Survey, a national survey of U.S. residents (n = 7720 participants, ages 1 to 80 years). General linear models and generalized additive models were used to examine the association between blood manganese concentration and participants’ characterisics, accounting for the complex survey design. Blood manganese levels ranged from 1.6 to 62.5 μg/L, with arithmetic means of 10.6 and 9.2 μg/L for women and men, respectively. The following characteristics were significantly associated with higher blood manganese levels: female sex, younger age, Asian origin, and being pregnant. In addition, there were non-linear relationships between blood manganese levels and cadmium, iron, lead, and mercury levels. The higher blood manganese levels observed among females suggest sex-related metabolic differences in the regulation of manganese, and elevated levels among pregnant women suggest an important role of manganese in reproduction. The present study supports the need to take into consideration age- and sex-related differences in blood manganese levels, as well as pregnancy status when examining manganese essentiality or toxicity.