Recent advances in the immunologic classification of leukemia.
Recent advances in the immunologic classification of leukemia.
复制标题
白血病免疫学分类的最新进展。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
R. Todd
中科院分区：
文献类型：
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作者：
K. Foon;R. Gale;R. Todd
通过使用定义细胞表面抗原的单抗和识别免疫球蛋白和T细胞受体基因的分子探针，已经获得了对白血病的白细胞分化和细胞起源的重要见解。这些研究的结果与B淋巴细胞表面膜和胞浆免疫球蛋白、T淋巴细胞上的绵羊红细胞受体和细胞化学染色等标记相结合。使用所有上述标记物，现在很明显，急性淋巴细胞性白血病(ALL)是异质性的。虽然单抗在鉴别急性髓系白血病和急性淋巴细胞性白血病方面很有用，但在急性髓系白血病(AML)的亚型划分上没有多少用处。正在尝试通过分化相关抗原而不是法国-美国-英国(FAB)分类对AML进行细分，以证明表面标记的潜在预后有用性。
Important insights into leukocyte differentiation and the cellular origins of leukemia have been gained through the use of monoclonal antibodies that define cell surface antigens and molecular probes that identify immunoglobulin and T cell receptor genes. Results of these studies have been combined with markers such as surface membrane and cytoplasmic immunoglobulin on B lymphocytes, sheep erythrocyte receptors on T lymphocytes, and cytochemical stains. Using all of the above markers, it is now clear that acute lymphoblastic leukemia (ALL) is heterogeneous. Although monoclonal antibodies are useful in distinguishing acute myeloid from acute lymphoid leukemias, they have less certain usefulness in the subclassification of acute myelogenous leukemia (AML). Attempts to subclassify AML by differentiation-associated antigens rather than by the French-American-British (FAB) classification are underway in order to document the potential prognostic usefulness of surface markers.