Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.
Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.
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DOI：
10.1016/j.schres.2009.09.038
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发表时间：
2009-12
影响因子：
4.5
通讯作者：
de Leon J
中科院分区：
文献类型：
--
作者：
Diaz FJ;Meary A;Arranz MJ;Ruaño G;Windemuth A;de Leon J
Acetyl-coenzyme A carboxylase α (ACACA) single-nucleotide polymorphism (SNP) (rs2229416) was significantly associated with hypertriglyceridemia, during exploration of antipsychotic direct effects on lipids. Neuropeptide Y (NPY) gene (rs1468271) and ACACB gene (rs2241220) SNPs were significantly associated with severe hypercholesterolemia. In the same sample (173 patients on olanzapine, quetiapine, chlorpromazine or mirtazapine [increasing the risk of hyperlipidemia] and 184 controls taking other antipsychotics), three (rs1266175, rs12453407 and rs9906543) of eight additional ACACA SNPs were significantly associated with hypertriglyceridemia in those taking drugs of interest, but not in controls. Five other ACACA SNPs, three additional NPY SNPs, or seven additional ACACB SNPs were not significant.
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影响因子：
4.5
作者：
de Leon, Jose;Correa, Juan Carlos;Diaz, Francisco J.
通讯作者：
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de Leon, Jose;Susce, Margaret T.;Diaz, Francisco J.
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影响因子：
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