Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection
Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection
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DOI：
10.1016/j.jaad.2005.03.057
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发表时间：
2006-02-01
影响因子：
13.8
通讯作者：
Hong, HS
中科院分区：
文献类型：
--
作者：
Chiou, CC;Chung, WH;Hong, HS
药物过敏综合征（DHS）是一种特殊的危及生命的药物不良反应，其特征是皮疹和多器官受累。在极少数情况下，暴发性1型糖尿病（DM）可在DHS后发展。在提出的发病机制中，人类疱疹病毒6 （HHV-6）感染可能在DHS的发展中起作用。我们报告一例DHS与HHV-6再激活相关，并伴有不可逆暴发性I型糖尿病的罕见后遗症。未检测到糖尿病相关的自身抗体。DHS患者应及早发现并干预这一严重并发症。暴发性1型糖尿病与DHS相关的综述。我们还讨论了HHV-6在与暴发性1型糖尿病相关的DHS中的作用。
Drug hypersensitivity syndrome (DHS) is an idiosyncratic and life-threatening adverse drug reaction characterized by skin rash and multiorgan involvement. In rare cases, fulminant type1 diabetes mellitus (DM) may develop after DHS. Among proposed pathogenesis, human herpesvirus 6 (HHV-6) infections may play a role in the development of DHS. We report a case of DHS associated with HHV-6 reactivation, complicated with a rare sequela of irreversible fulminant type I DM. No diabetes-related autoantibodies were detected. Early detection and intervention for this serious complication should be given in patients with DHS. Fulminant type1 DM associated with DHS is reviewed. The role of HHV-6 in DHS associated with fulminant type 1 DM is also discussed.