G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke
G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke
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DOI：
10.1016/j.brainres.2006.08.091
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发表时间：
2006-11-22
期刊：
影响因子：
2.9
通讯作者：
Suzuki, Norihiro
中科院分区：
文献类型：
--
作者：
Hattori, Hidenori;Sonoda, Akira;Suzuki, Norihiro
人凝集素样氧化低密度脂蛋白受体1（OLR 1/LOX-1）是抗氧化低密度脂蛋白（Ox-LDL）的主要内皮清道夫受体，参与动脉粥样硬化的发病机制。我们使用单核苷酸引物延伸分析（SNuPe）研究了235例日本缺血性脑血管病（CVD）患者和274例年龄和性别匹配的健康对照者OLR 1基因的G501 C突变。缺血性CVD患者和对照组之间的多态性无显著差异（GC + CC vs GG，p = 0.48）。C等位基因在患者和对照组之间没有显著差异（C对G，p=0.91）。我们的研究结果表明，OLR 1基因多态性对日本人群缺血性CVD风险增加的影响不大。(c)2006 Elsevier B. V.保留所有权利。
The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p=0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population. (c) 2006 Elsevier B.V. All rights reserved.