A large outbreak of epidemic keratoconjunctivitis: problems in controlling nosocomial spread.
A large outbreak of epidemic keratoconjunctivitis: problems in controlling nosocomial spread.
复制标题
流行性角结膜炎大爆发：控制院内传播的问题。
DOI：
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发表时间：
1989
影响因子：
6.4
通讯作者：
Larry J. Anderson
中科院分区：
文献类型：
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作者：
D. Warren;K. Nelson;J. Farrar;E. Hurwitz;J. Hierholzer;Earl Ford;Larry J. Anderson
1985年7月至1986年1月，在伊利诺伊州眼耳医院发现了401例腺病毒流行性角膜结膜炎（EKC）患者。其中110例（27%）为院内感染，其他291例患者为社区获得性感染。EKC的最高发病率发生在专科门诊患者中;门诊患者的总体发病率为4.7/1000次门诊就诊。所有医院感染病例均由腺病毒8型引起;社区获得性病例为腺病毒8型和37型的混合物。临床疾病发作后14天，从结膜培养物中分离出腺病毒。最初的努力，以防止医院传播是不成功的。然而，当实施一项计划，对所有进入医务室的患者进行分诊，并将患者和护理受感染患者的人员分类到队列中时，尽管社区流行病持续了4个月，但EKC的医院传播迅速有效地停止了。这次暴发清楚地表明了严格的感染控制在预防腺病毒EKC医院传播中的有效性。
Between July 1985 and January 1986, 401 patients with adenovirus epidemic keratoconjunctivitis (EKC) were seen at the Illinois Eye and Ear Infirmary. Of the cases, 110 (27%) were nosocomial; the other 291 patients had community acquired infection. The highest attack rates of EKC occurred in patients attending specialty clinics; the overall attack rate among clinic patients was 4.7/1,000 clinic visits. All nosocomial cases were caused by adenovirus type 8; community acquired cases were a mixture of adenovirus types 8 and 37. Adenoviruses were isolated from conjunctival cultures up to 14 d after the onset of clinical illness. Initial efforts to prevent nosocomial transmission were unsuccessful. However, when a plan to triage all patients on entry to the infirmary and to sort patients and personnel caring for infected patients into cohorts was implemented, nosocomial transmission of EKC was promptly and effectively halted, despite the continuation of the community epidemic for another 4 mo. This outbreak clearly demonstrates the efficacy of rigorous infection control in preventing nosocomial transmission of adenovirus EKC.