Expression of the RNA binding proteins, Mel-N1, Mel-N2, and Mel-N3 in adipose cells.
Expression of the RNA binding proteins, Mel-N1, Mel-N2, and Mel-N3 in adipose cells.
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DOI：
10.1016/s0006-291x(02)00472-2
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发表时间：
2002-06
影响因子：
3.1
通讯作者：
Chen Qi;J. Wheeler;A. Pruett;P. Pekala
中科院分区：
文献类型：
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作者：
Chen Qi;J. Wheeler;A. Pruett;P. Pekala
Mel-N1（小鼠胚胎致死性视力异常 [ELAV]）是果蝇 ELAV 的哺乳动物同源物，是 RNA 识别基序家族的 mRNA 结合蛋白。对人类同源物 Hel-N1 的研究支持了这样的假设：Hel-N1 及其剪接变体 Hel-N2 在 mRNA 代谢中发挥作用。因此，将这一假设扩展到小鼠变体 Mel-N1 变得合乎逻辑，该变体已被描述为在睾丸中具有少量表达水平的神经元蛋白。我们目前的工作通过证明全长信息和剪接变体在脂肪组织以及前脂肪细胞和脂肪细胞系中的表达，扩展了该蛋白质的潜在功能。
Mel-N1 (murine embryonic lethal abnormal vision [ELAV]), a mammalian homolog of Drosophila ELAV, is an mRNA binding protein of the RNA Recognition Motif family. Studies with the human homolog, Hel-N1 have supported the hypothesis that Hel-N1, and its splice variant, Hel-N2 play a role in mRNA metabolism. Thus it becomes logical to extend this hypothesis to the murine variant Mel-N1 which has been described as a neuronal protein with a minor level of expression in the testis. Our current work expands the potential function for this protein through demonstration of expression of the full-length message and splice variants in adipose tissue as well as preadipocyte and adipocyte cell lines.