The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes
The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes
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DOI：
10.1016/s0925-4773(98)00212-3
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发表时间：
1999-02-01
影响因子：
2.6
通讯作者：
Preiss, A
中科院分区：
文献类型：
--
作者：
Wurmbach, E;Wech, I;Preiss, A
高等动物中的许多细胞命运决定是基于Notch信号通路控制的细胞间通信。Notch受体接收的发育信号导致无毛抑制因子（Suppressor of Hairless，Su（H））介导靶基因的转录。在果蝇中，迄今已知的大多数Notch靶基因位于分裂复合物的增强子（E（spl）-C）中，编码小的碱性螺旋-环-螺旋（bHLH）蛋白，其可能充当转录阻遏物。在这里，我们表明，E（spl）-C含有三个额外的Notch响应，非bHLH基因：M4和M α的结构相关，而M2编码一种新的蛋白质。所有三个基因都依赖于Su（H）来启动和/或维持转录。该基因座内的另外两个非bHLH基因m1和m6与Notch途径无关：m1可能编码Kazal家族的蛋白酶抑制剂，m6编码一种新的肽。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
Many cell fate decisions in higher animals are based on intercellular communication governed by the Notch signaling pathway. Developmental signals received by the Notch receptor cause Suppressor of Hairless (Su(H)) mediated transcription of target genes. In Drosophila, the majority of Notch target genes known so far is located in the Enhancer of split complex (E(spl)-C), encoding small basic helix-loop-helix (bHLH) proteins that presumably act as transcriptional repressors. Here we show that the E(spl)-C contains three additional Notch responsive, non-bHLH genes: m4 and m alpha are structurally related, whilst m2 encodes a novel protein. All three genes depend on Su(H) for initiation and/or maintenance of transcription. The two other non-bHLH genes within the locus, m1 and m6, are unrelated to the Notch pathway: mi might code for a protease inhibitor of the Kazal family, and m6 for a novel peptide. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.