Effect of inspiratory muscle training with load compared with sham training on blood pressure in individuals with hypertension: study protocol of a double-blind randomized clinical trial
Effect of inspiratory muscle training with load compared with sham training on blood pressure in individuals with hypertension: study protocol of a double-blind randomized clinical trial
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DOI：
10.1186/s13063-016-1514-y
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发表时间：
2016-08-02
期刊：
影响因子：
2.5
通讯作者：
Moreira, Leila Beltrami
中科院分区：
文献类型：
--
作者：
Posser, Simone Regina;Callegaro, Carine Cristina;Moreira, Leila Beltrami
背景：高血压是一种以动脉血压升高为特征的复杂慢性疾病。高血压的管理包括非药物策略，其中可能包括有效减少自主交感神经活动的技术。呼吸练习可改善心血管系统的自主控制，减弱肌肉代谢反射。由于这些影响，呼吸练习可能是有用的，以降低血压在高血压subjects.Methods/设计：这个随机，双盲临床试验将测试吸气肌训练在降低血压的成人原发性高血压的疗效。受试者被随机分配到干预组或对照组。干预包括吸气肌训练，负荷为最大吸气压力的40%，每周重新调整。控制假干预包括无负荷练习。收缩压和舒张压是通过24小时动态血压监测评估的共同主要终点指标。次要结果指标包括心血管自主控制、吸气肌代谢反射、心肺功能、吸气肌力量和耐力。讨论：以前发表的工作表明，吸气肌训练可降低高血压患者的血压，但这种干预的有效性尚未确定。我们提出了一个足够大的随机临床试验来严格检验这一假设。如果发现效应，本研究将允许调查介导该效应的假定机制，包括自主心血管控制和代谢反射。
Background: Hypertension is a complex chronic condition characterized by elevated arterial blood pressure. Management of hypertension includes non-pharmacologic strategies, which may include techniques that effectively reduce autonomic sympathetic activity. Respiratory exercises improve autonomic control over cardiovascular system and attenuate muscle metaboreflex. Because of these effects, respiratory exercises may be useful to lower blood pressure in subjects with hypertension.Methods/design: This randomized, double-blind clinical trial will test the efficacy of inspiratory muscle training in reducing blood pressure in adults with essential hypertension. Subjects are randomly allocated to intervention or control groups. Intervention consists of inspiratory muscle training loaded with 40 % of maximum inspiratory pressure, readjusted weekly. Control sham intervention consists of unloaded exercises. Systolic and diastolic blood pressures are co-primary endpoint measures assessed with 24 h ambulatory blood pressure monitoring. Secondary outcome measures include cardiovascular autonomic control, inspiratory muscle metaboreflex, cardiopulmonary capacity, and inspiratory muscle strength and endurance.Discussion: Previously published work suggests that inspiratory muscle training reduces blood pressure in persons with hypertension, but the effectiveness of this intervention is yet to be established. We propose an adequately sized randomized clinical trial to test this hypothesis rigorously. If an effect is found, this study will allow for the investigation of putative mechanisms to mediate this effect, including autonomic cardiovascular control and metaboreflex.