DIURNAL-VARIATION OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR AND ITS RAPID INHIBITOR (PAI-1)
DIURNAL-VARIATION OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR AND ITS RAPID INHIBITOR (PAI-1)
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DOI：
10.1161/01.cir.79.1.101
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发表时间：
1989-01-01
期刊：
影响因子：
37.8
通讯作者：
SCHMER, G
中科院分区：
文献类型：
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作者：
ANGLETON, P;CHANDLER, WL;SCHMER, G
先前的研究表明，血液中的总纤溶活性遵循昼夜节律，在早晨达到峰值，在晚上达到谷值。本研究的目的是确定哪些纤溶因子（S）负责这种昼夜节律。对33名健康男性（平均年龄31岁）和15名既往有心肌梗死或不稳定型心绞痛的患者（平均年龄57岁）在早晨和晚上测定静息和静脉闭塞后组织型纤溶酶原激活物（t-PA）活性、静息t-PA抗原和静息纤溶酶原激活物抑制物1（派-1）活性。派-1活性和t-PA抗原在早晨均显著高于晚上（P < 0.01）。相反，两组的静息t-PA活性在早晨显著降低（p < 0.01），并且与派-1活性呈负相关（r =-0.57，p < 0.0001）。静脉闭塞后t-PA活性和t-PA容量在两组中的早晨和晚上之间没有显著差异。由于t-PA抗原水平和派-1活性在早晨最高，因此t-PA活性的变化可能不是由于t-PA分泌减少，而是由于派-1分泌的变化。我们的研究结果表明，派-1活性的昼夜变化可能会降低健康个体和冠状动脉疾病患者早晨的纤溶活性。
Previous studies have shown that overall fibrinolytic activity in blood follows a diurnal rhythm with a peak in the morning and a trough in the evening. The purpose of this study was to determine which fibrinolytic factor(s) was responsible for this diurnal rhythm. Resting and postvenous occlusion tissue-type plasminogen activator (t-PA) activity, resting t-PA antigen, and resting plasminogen activator inhibitor 1 (PAI-1) activity were measured in the morning and evening in 33 healthy men (mean age, 31 years) and in 15 patients (mean age, 57 years) with previous myocardial infarction or unstable angina. PAI-1 activity and t-PA antigen were significantly higher (p < 0.01) in the morning compared with the evening in controls and patients. In contrast, resting t-PA activity was significantly lower in the morning (p < 0.01) in both groups and was inversely correlated with PAI-1 activity (r = -0.57, p < 0.0001). Postvenous occlusion t-PA activity and t-PA capacity were not significantly different between morning and evening in either group. Because t-PA antigen levels and PAI-1 activity were highest in the morning, the variation in t-PA activity was probably not due to decreased secretion of t-PA but instead to changes in the secretion of PAI-1. Our findings indicate that diurnal variations in PAI-1 activity may reduce fibrinolytic activity in the morning in healthy individuals and in patients with coronary artery disease.