Urinary leukotriene E4
Urinary leukotriene E4
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DOI：
10.1016/j.iac.2007.09.004
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发表时间：
2007-11-01
影响因子：
2.6
通讯作者：
Rabinovitch, Nathan
中科院分区：
文献类型：
--
作者：
Rabinovitch, Nathan
尿白三烯E-4（LTE 4）的测量是一种灵敏和非侵入性的方法，用于测定全身半胱氨酰白三烯的产生和特定微环境（如气道）中半胱氨酰白三烯水平的变化。尿液LTE 4测量可用作暴露于哮喘触发因素（如空气污染和病毒感染）的敏感生物标志物。最近的研究表明，使用尿LTE 4浓度作为哮喘控制的预测因子和对白三烯受体拮抗剂治疗敏感性的标志物的潜力。
Measurement of urinary leukotriene E-4 (LTE4) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene levels in specific microenvironments, such as the airway. Urinary LTE4 measurements can be used as sensitive biomarkers of exposure to asthma triggers, such as air pollution and viral infections. Recent studies suggest the potential of using urinary LTE4 concentrations as predictors of asthma control and markers of susceptibility to treatment with leukotriene receptor antagonists.