Usefulness of [11C]methionine PET in the diagnosis of dysembryoplastic neuroepithelial tumor with temporal lobe epilepsy
Usefulness of [11C]methionine PET in the diagnosis of dysembryoplastic neuroepithelial tumor with temporal lobe epilepsy
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DOI：
10.1111/j.0013-9580.2004.20703.x
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发表时间：
2004-01-01
期刊：
影响因子：
5.6
通讯作者：
Ohno, K
中科院分区：
文献类型：
--
作者：
Maehara, T;Nariai, T;Ohno, K
目的：探讨[C-11]蛋氨酸(MET)正电子发射断层扫描(PET)对伴发于颞叶癫痫(TLE)的良性肿瘤中胚胎发育不良神经上皮性肿瘤(DNETs)的鉴别诊断价值。在MET-PET研究后，所有7名患者都接受了肿瘤切除和病灶切除。通过病灶对对侧的比值(L/C比)和标准化摄取值来评估示踪剂的摄取。我们还评估了手术标本中MET摄取与增殖能力的关系。结果：4例DNETs患者在视觉上没有显示高MET摄取，其余3例患者的神经节胶质瘤和胶质瘤被确定为高MET摄取病变。在DNETS中，SUV介乎1.03至1.41，L/C比率介乎0.99至1.14。DNETS患者的MET摄取显著低于神经节细胞瘤和脑胶质瘤患者(SUV，p=0.045；L/C比值，p=0.0079)。1例dNet和1例多形性黄色星形细胞瘤Ki-67标记指数分别为4%和5%(标记指数较高)。高标记指数与高摄取MET无关(P=0.91)和L/C比值(P=0.38)。结论：良性颞叶肿瘤合并TLE的MET摄取阴性与DNET的术前诊断一致。
Purpose: We assessed the diagnostic value of [C-11]methionine (MET) positron emission tomography (PET) in the differential diagnosis of dysembryoplastic neuroepithelial tumors (DNETs) among benign tumors associated with temporal lobe epilepsy (TLE).Methods: This series consisted of seven TLE patients with benign tumors in the temporal lobe. After MET-PET study, all seven patients underwent tumor resection along with focus excision. The uptake of tracers was evaluated by the lesion-to-contralateral ratio (L/C ratio) and the standardized uptake value (SUV). We also assessed the relation between MET uptake and proliferation capacity observed in the surgical specimens.Results: Whereas four patients with DNETs did not show high MET uptake visually, the ganglioglioma and gliomas of the remaining three patients were identified as high-MET-uptake lesions. In the DNETs, the SUV ranged from 1.03 to 1.41, and the L/C ratio ranged from 0.99 to 1.14. MET uptake was significantly lower in the patients with DNETs than in the patients with ganglioglioma and brain gliomas (SUV, p=0.045; L/C ratio, p=0.0079). The Ki-67 labeling index was 4% in one patient with DNET and 5% in one patient with pleomorphic xanthoastrocytoma (higher labeling index). The higher labeling index was not related to high MET uptake based on the SUV (p=0.91) and L/C ratio (p=0.38).Conclusions: Negative MET uptake in benign temporal lobe tumors with TLE is consistent with a preoperative diagnosis of DNET.