A narrative review of clinical manifestations and pathogenetic mechanisms of neuropathy induced by radiation therapy
A narrative review of clinical manifestations and pathogenetic mechanisms of neuropathy induced by radiation therapy
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DOI：
10.4103/jrcr.jrcr_57_21
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发表时间：
2022-07
影响因子：
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通讯作者：
Atsuto Katano
中科院分区：
文献类型：
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作者：
Atsuto Katano
癌症治疗的放射疗法可能会对神经系统造成损害。尽管随着手术、放射治疗和系统治疗等治疗方法的进步，癌症患者的总体存活率有所提高。评估放射治疗引起的晚期不良事件，如认知功能减退、脑坏死和放射诱导的肿瘤形成，是至关重要的。这些不良事件大多是不可逆转的，可能会显著降低生活质量。放射治疗损害神经细胞的机制尚不完全清楚，神经元对辐射的抵抗力可能不像以前认为的那样。在癌症治疗策略中权衡放射治疗的好处与可能发生的急性和晚期不良事件的风险是重要的。建议对这些情况进行长期随访，以提高存活率和生活质量。本文就放射性神经病的临床表现和发病机制作一综述。
Radiation therapy for cancer treatment can cause damage to the nervous system. Although the overall survival of cancer patients has increased with advances in therapy, such as surgery, radiotherapy, and systemic therapy. It is critical to assess the late adverse events caused by radiation therapy, such as cognitive decline, brain necrosis, and radiation-induced tumorigenesis. These adverse events are mostly irreversible and can significantly decrease the quality of life. The mechanism by which radiation therapy damages nerve cells is not fully understood, and neurons may not be as resistant to radiation as previously thought.It is important to weigh the benefits of radiation therapy in cancer treatment strategies against the possible risks of both acute and late adverse events. Long-term follow-up with these conditions is advised to improve survival and quality of life. This narrative review focused on the clinical manifestations and pathogenetic mechanisms of radiation-induced neuropathy.