EFFECT OF REDUCED RED-CELL DEFORMABILITY ON FLOW VELOCITY IN CAPILLARIES OF RAT MESENTERY
EFFECT OF REDUCED RED-CELL DEFORMABILITY ON FLOW VELOCITY IN CAPILLARIES OF RAT MESENTERY
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DOI：
10.1007/bf00582631
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发表时间：
1980-01-01
影响因子：
4.5
通讯作者：
SCHMIDSCHONBEIN, H
中科院分区：
文献类型：
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作者：
DRIESSEN, GK;HAEST, CWM;SCHMIDSCHONBEIN, H
用SH氧化剂联胺处理大鼠红细胞(RBC)，可使红细胞变形性逐渐降低。用等容交换的方法将60%的天然RBC注入大鼠体内，测量大鼠肠系膜毛细血管的RBC血流速度。在正常平均动脉压下，接受0.5 mmol/L联胺硬化细胞的大鼠红细胞流速下降29%。用1.5 mmoL/L联胺进一步硬化红细胞，仅使血流量减少15%。降压期间，红细胞流速骤降至8.+-。0.5nmol/L为15%，降至2+-。1.5mmo1/L联胺组较常压时血流速度增加6%。显微镜下可观察到许多血管内血流停止。讨论了正常的红细胞变形性对于维持微循环的充分灌流的重要性，特别是在低血压梯度时。
A graded reduction of deformability of red blood cells (RBC) of rats was obtained by treatment with the SH-oxidizing agent diamide. Rigidified RBC were injected into rats by isovolemic exchange against 60% of the native RBC and RBC flow velocities was measured in capillaries of the rat mesentery. At normal mean arterial pressure RBC flow velocity decreases by 29% in rats receiving cells rigidified with 0.5 mmol/l diamide. A further rigidification of erythrocytes by 1.5 mmol/l diamide results in a decrease of flow by only 15%. During hypotension RBC flow velocities dropped precipitously to 8 .+-. 15% for the 0.5 nmol/l and to 2 .+-. 6% for the 1.5 mmol/l diamide group compared to velocities during normotension. By microscopy a stop of flow in many vessels was observed. The importance of a normal red cell deformability for the maintenance of sufficient perfusion of the microcirculation, in particular at low blood pressure gradients, is discussed.