Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD.
Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD.
复制标题
哌醋甲酯和安非他明不会引起多动症儿童淋巴细胞的细胞遗传学损伤。
DOI：
10.1097/chi.0b013e3181893620
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发表时间：
2008
影响因子：
13.3
通讯作者：
Kollins,ScottH
中科院分区：
文献类型：
--
作者：
Witt,KristineL;Shelby,MichaelD;Itchon-Ramos,Nilda;Faircloth,Melissa;Kissling,GraceE;Chrisman,AllanK;Ravi,Hima;Murli,Hemalatha;Mattison,DonaldR;Kollins,ScottH
为了回应先前发表的哌甲酯诱导儿童染色体改变的研究结果，本研究旨在确定哌甲酯或安非他明类药物是否诱导染色体损伤（结构畸变，微核，和姐妹染色单体交换）在外周血淋巴细胞的儿童注意缺陷/多动障碍后3个月的连续治疗。6至12岁，整体健康状况良好，并根据DSM-IV标准严格诊断的ADHD被判定为兴奋剂治疗的适当候选人，被随机分为两个开放标签治疗组（哌甲酯或混合安非他明盐）。每例受试者在治疗开始前和治疗3个月后提供血液样本。治疗前和治疗后的染色体畸变，微核，和姐妹染色单体交换的频率进行了测定，为每个subjects. CITTSSixthree受试者参加了这项研究，47名受试者完成了完整的3个月的治疗，25在哌甲酯组和22在安非他明组。没有显着的治疗相关的增加，观察到在任何三个措施的细胞遗传学损伤的47例受试者谁完成治疗或16例受试者谁没有。CONCLUSIONSEarlier发现phenidate诱导的染色体变化的儿童在这项研究中没有复制。这些结果增加了越来越多的证据表明，治疗水平的哌甲酯不会诱导人类细胞遗传学损伤。此外，我们的研究结果表明，苯丙胺类药物不会对儿童造成细胞遗传学损伤。
OBJECTIVEIn response to previously published findings of methylphenidate-induced chromosomal changes in children, this study was designed to determine whether methylphenidate- or amphetamine-based drugs induce chromosomal damage (structural aberrations, micronuclei, and sister chromatid exchanges) in peripheral blood lymphocytes of children with attention-deficit/hyperactivity disorder after 3 months of continuous treatment.METHODStimulant drug-naïve subjects, 6 to 12 years of age, in good overall health, and judged to be appropriate candidates for stimulant therapy based on rigorously diagnosed ADHD using DSM-IV criteria, were randomized into two open-label treatment groups (methylphenidate or mixed amphetamine salts). Each subject provided a blood sample before initiation of treatment and after 3 months of treatment. Pretreatment and posttreatment frequencies of chromosomal aberrations, micronuclei, and sister chromatid exchanges were determined for each subject.RESULTSSixty-three subjects enrolled in the study; 47 subjects completed the full 3 months of treatment, 25 in the methylphenidate group and 22 in the amphetamine group. No significant treatment-related increases were observed in any of the three measures of cytogenetic damage in the 47 subjects who completed treatment or the 16 subjects who did not.CONCLUSIONSEarlier findings of methylphenidate-induced chromosomal changes in children were not replicated in this study. These results add to the accumulating evidence that therapeutic levels of methylphenidate do not induce cytogenetic damage in humans. Furthermore, our results indicate that amphetamine-based products do not pose a risk for cytogenetic damage in children.