Selective suppressive effects of glucocorticoids on the early events in the human B cell activation process.
Selective suppressive effects of glucocorticoids on the early events in the human B cell activation process.
复制标题
糖皮质激素对人类 B 细胞激活过程早期事件的选择性抑制作用。
作者：
D. Bowen;A. Fauci
已经描述了氢化可的松对人B细胞活化和增殖的诱导作用。氢化可的松可防止抗mu诱导的小扁桃体B细胞的细胞增大，阻断抗mu诱导的活化标记物4F2和5E9的表达，抑制抗mu（含或不含BCGF）刺激的小B细胞的RNA合成，并抑制B细胞对抗mu和BCGF或金黄色葡萄球菌科万I的应答增殖。相反，氢化可的松不影响体外或体内预活化B细胞的增殖反应。因此，氢化可的松对人B细胞周期中的早期事件具有选择性抑制作用，其随后导致总RNA和DNA合成的抑制。这种行动的可能机制进行了讨论。这些研究进一步确定了糖皮质激素诱导的人B细胞活化和增殖调节的性质。
The effect of hydrocortisone on the induction of human B cell activation and proliferation has been described. Hydrocortisone prevents the anti-mu-induced cell enlargement of small tonsillar B cells, blocks expression of the activation markers 4F2 and 5E9 induced by anti-mu, inhibits RNA synthesis of small B cells stimulated by anti-mu with or without BCGF, and suppresses B cell proliferation in response to anti-mu and BCGF or to Staphylococcus aureus Cowan I. In contrast, hydrocortisone does not affect the proliferative response of in vitro or in vivo preactivated B cells. Therefore, hydrocortisone has a selective inhibitory effect on early events in the human B cell cycle that subsequently leads to inhibition of total RNA and DNA synthesis. Possible mechanisms of this action are discussed. These studies further define the nature of glucocorticoid-induced modulation of human B cell activation and proliferation.