Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation
Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation
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DOI：
10.1074/jbc.m511920200
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发表时间：
2006-04-28
影响因子：
4.8
通讯作者：
Tang, SJ
中科院分区：
文献类型：
--
作者：
Chen, JY;Park, CS;Tang, SJ
Wnt对各种发育和致癌过程都很重要。在这里，我们表明，Wnt信号功能在海马神经元的突触。强直刺激诱导N-甲基-D-天冬氨酸受体依赖性突触Wnt 3a释放、核β-连环蛋白积累和Wnt靶基因的激活。抑制Wnt信号传导损害长时程增强。相反，Wnt信号传导的激活促进长时程增强。这些发现表明，Wnt信号在调节突触可塑性中起着关键作用。
Wnts are important for various developmental and oncogenic processes. Here we show that Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-methyl-D-aspartate receptor-dependent synaptic Wnt3a release, nuclear beta-catenin accumulations, and the activation of Wnt target genes. Suppression of Wnt signaling impairs long term potentiation. Conversely, activation of Wnt signaling facilitates long term potentiation. These findings suggest that Wnt signaling plays a critical role in regulating synaptic plasticity.