Effect of bilayer thickness on membrane bending rigidity
Effect of bilayer thickness on membrane bending rigidity
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DOI：
10.1021/la035497f
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发表时间：
2004-02-03
期刊：
影响因子：
3.9
通讯作者：
Discher, DE
中科院分区：
文献类型：
--
作者：
Bermúdez, H;Hammer, DA;Discher, DE
用单微量移液器和双微量移液器技术测量了两亲性嵌段共聚物自组装双层囊泡的弯曲刚度k（c）。这些共聚物的疏水膜厚度d比它们的脂质对应物大近5倍，分子量M-n大一个数量级。这些两亲物的大分子结构有助于深入了解并扩展传统表面活性剂行为的关系。我们发现k（c）与厚度的比例接近二次方，与现有的双层膜理论很好地吻合。这里的结果是理解和设计软界面，如生物膜模拟的关键。
The bending rigidity k(c) of bilayer vesicles self-assembled from amphiphilic diblock copolymers has been measured using single- and dual-micropipet techniques. These copolymers are nearly a factor of 5 greater in hydrophobic membrane thickness d than their lipid counterparts and an order of magnitude larger in molecular weight M-n. The macromolecular structure of these amphiphiles lends insight into and extends relationships for traditional surfactant behavior. We find the scaling of k(c) with thickness to be nearly quadratic, in good agreement with existing theories for bilayer membranes. The results here are key to understanding and designing soft interfaces such as biomembrane mimetics.