A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders
A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders
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DOI：
10.1007/s007740200038
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发表时间：
2002
影响因子：
3.3
通讯作者：
T. Juji;M. Hertz;K. Aoki;Daisuke Horie;K. Ohya;A. Gautam;S. Mouritsen;H. Oda;Kozo Nakamura;Sakae Tanaka
中科院分区：
文献类型：
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作者：
T. Juji;M. Hertz;K. Aoki;Daisuke Horie;K. Ohya;A. Gautam;S. Mouritsen;H. Oda;Kozo Nakamura;Sakae Tanaka
越来越多的证据表明，RANKL在病理性骨破坏中也起重要作用，如绝经后骨质疏松症和类风湿性关节炎（RA）。据报道，RANKL转录本在卵巢切除大鼠的骨组织中大量表达[1]，我们和其他研究小组最近报道RANKL在RA患者的滑膜组织中高度表达[2，3]。OPG对这些病理状况具有有效的治疗作用，如不同研究组所报告的：即OPG改善卵巢切除大鼠的骨丢失[4]，腺病毒载体诱导的OPG产生防止卵巢切除小鼠的骨丢失[5]，OPG防止骨破坏
There is accumulating evidence that RANKL also plays an important role in pathological bone destruction, such as that in postmenopausal osteoporosis and rheumatoid arthritis (RA). It has been reported that RANKL transcripts were expressed abundantly in the bone tissue of ovariectomized rats [1], and we and other groups recently reported that RANKL was highly expressed in the synovial tissues of RA patients [2, 3]. OPG has potent therapeutic effects on such pathological conditions, as reported by various groups: ie, OPG ameliorated bone loss in ovariectomized rats [4], adenovirus vectorinduced OPG production prevented bone loss in ovariectomized mice [5], OPG prevented bone destruction