Prognostic factors in renal carcinoma.
Prognostic factors in renal carcinoma.
复制标题
肾癌的预后因素。
作者：
B. Rini;N. Vogelzang
鉴定肾癌（RC）中与肿瘤、患者或治疗相关的预后因素将使当前和未来的治疗最适合应用于这种反应不佳的恶性肿瘤患者。分期（包括淋巴结和静脉受累程度）和分级仍然是患者预后最有力的预测因素。患者的体能状态（PS）也会影响预后，因为它与肿瘤的侵袭性和接受充分治疗的能力有关。目前正在探索测量肿瘤增殖的新技术以及细胞遗传学在 RC 中的应用，并可能有助于预测。最后，肿瘤转移的特征以及手术和化疗治疗方式的适当应用可以识别具有不同生存时间的患者亚组。本综述探讨了影响 RC 患者总生存期的各种特征。
Identification of tumor-, patient-, or treatment-related prognostic factors in renal carcinoma (RC) would allow the most appropriate application of current and future therapy to patients with this poorly responsive malignancy. Stage, including degree of lymph node and venous involvement, and grade remain the most powerful predictors of patient outcome. Performance status (PS) of patients also influences prognosis, as it relates to tumor aggressiveness and ability to receive adequate treatment. Newer techniques of measuring tumor proliferation and the application of cytogenetics to RC are currently being explored and may add to prognostication. Lastly, characteristics of tumor metastases and the appropriate application of surgical and chemotherapeutic treatment modalities allow for identification of patient subgroups with different survival times. This review explores various characteristics as they impact on overall survival in patients with RC.