Relationship of resting hemoglobin concentration to peak oxygen uptake in heart failure patients
Relationship of resting hemoglobin concentration to peak oxygen uptake in heart failure patients
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DOI：
10.1002/ajh.21698
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发表时间：
2010-06-01
影响因子：
12.8
通讯作者：
Apostolo, Anna
中科院分区：
文献类型：
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作者：
Agostoni, Piergiuseppe;Salvioni, Elisabetta;Apostolo, Anna
贫血在慢性心力衰竭(HF)中很常见。为了计算峰值摄氧量((V)比Doto(2))在血红蛋白浓度变化的情况下应该发生什么变化，我们研究了峰值(V)比Doto(2)与大量HF人群中血红蛋白浓度的相关性。我们对2001年6月至2009年3月在我们心力衰竭诊所进行的所有心肺运动试验(CPET)患者进行了回顾性分析，这些患者在CPET后7天内进行了静息血红蛋白浓度测量。我们收集了967个CPET，704个测试被认为是最大值并进行了分析。我们发现181名患者(26%)患有贫血。贫血患者DOTO(2)的峰值(V)为97123ml/m in，明显低于非贫血患者(1243±18m l/m in)(P<0.001)。在高峰运动时，(V)/Doto(2)与Hb比率的斜率为109ml/min/g/dl。当对几个混杂变量进行多变量分析时，这种相关性仍然显著。分析。平均而言，在运动高峰时，每克血红蛋白引起(V)比Doto(2)的变化为109毫升/分钟，相当于0.97毫升/分钟/公斤。因此，在心衰患者中，每增加1 g/dl的血红蛋白，贫血治疗应比DOTO(2)增加109毫升/分钟。上午好。J.血醇。2010年，85：414-417。(C)2010年Wiley-Liss公司
Anemia is frequent in chronic heart failure (HF). To calculate what change in peak oxygen uptake ((V) over dotO(2)) should be expected in the event of changes in hemoglobin concentration, we studied the correlation between peak (V) over dotO(2) and hemoglobin concentration in a large HF population. We carried out retrospective analysis of all cardiopulmonary exercise tests (CPET) performed in our HF Clinic between June 2001 and March 2009 in HF patients who had a resting hemoglobin concentration measurement taken within 7 days of the CPET. We collected 967 CPETs, 704 tests were considered maximal and analyzed. We identified 181 patients (26%) as anemic. Peak (V) over dotO(2) was lower (P < 0.001) in anemic patients (971 23 ml/min) compared with nonanemic (1243 +/- 18 ml/min). The slope of the (V) over dotO(2) vs. hemoglobin ratio was 109 ml/min/g/dl at peak exercise. This correlation remained significant also when several confounding variables were analyzed by multivariate. analysis. As an average, each gram of hemoglobin accounts, at peak exercise, for 109 ml/min change in (V) over dotO(2) which is equivalent to 0.97 ml/min/kg. Therefore, in HF patients anemia treatment should increase (V) over dotO(2) by 109 ml/min for each g/dl of hemoglobin increase. Am. J. Hematol. 85:414-417, 2010. (C) 2010 Wiley-Liss, Inc.