Single-cell directional sensing from just a few receptor binding events
Single-cell directional sensing from just a few receptor binding events
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DOI：
10.1016/j.bpj.2023.06.015
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发表时间：
2023-08-08
影响因子：
3.4
通讯作者：
Lindsay，Alan E.
中科院分区：
文献类型：
--
作者：
Bernoff，Andrew J.;Jilkine，Alexandra;Lindsay，Alan E.
识别从噪声输入到膜受体的信号源的方向性是许多细胞类型执行的基本任务。已经提出了各种模型来解释细胞中的方向感测。然而，这些中的许多需要显著的计算和存储器容量的细胞。我们提出并分析了一个简单的机制，其中一个细胞采用的方向与前几个膜结合事件。该模型产生一个准确的角度估计源之前，达到稳定状态，在生物相关的情况下。我们提出的机制允许使用时间信息的外部信号的方向性的可靠估计，并假设最小的计算能力的细胞。
Identifying the directionality of signaling sources from noisy input to membrane receptors is an essential task performed by many cell types. A variety of models have been proposed to explain directional sensing in cells. However, many of these require significant computational and memory capacities for the cell. We propose and analyze a simple mechanism in which a cell adopts the direction associated with the first few membrane binding events. This model yields an accurate angular estimate to the source long before steady state is reached in biologically relevant scenarios. Our proposed mechanism allows for reliable estimates of the directionality of external signals using temporal information and assumes minimal computational capacities of the cell.