Cell based therapy for the management of chronic pain.
Cell based therapy for the management of chronic pain.
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DOI：
10.4097/kjae.2011.60.1.3
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发表时间：
2011-01
影响因子：
2.9
通讯作者：
Jeon Y
中科院分区：
文献类型：
--
作者：
Jeon Y
慢性疼痛的管理，特别是神经性疼痛，仍然有大量未得到满足的需求。除了症状缓解不足外，还有对与治疗相关的不良反应和成瘾的担忧。将分泌具有止痛特性的神经活性物质的细胞移植到中枢神经系统中只是在最近几年才开始引起实用兴趣，但它提供了一种新的策略来挑战目前治疗慢性疼痛的方法。这篇综述包括临床前和临床研究，包括异体和异体来源的慢性顽固性疼痛的治疗。
The management of chronic pain, particularly neuropathic pain, still has significant unmet needs. In addition to inadequate symptomatic relief, there are concerns about adverse effects and addiction associated with treatments. The transplantation of cells that secrete neuroactive substances with analgesic properties into the central nervous system has only become of practical interest in more recent years, but provides a novel strategy to challenge current approaches in treating chronic pain. This review covers pre-clinical and clinical studies from both allogeneic and xenogeneic sources for management of chronic refractory pain.